IKK激酶的NF-κB非相关性功能研究进展  

Research Progress on the NF-κB-Independent Functions of IKK Complex

作　　者：胡永亮[1,2] 宋伦[1] 

机构地区：[1]军事医学科学院基础医学研究所应激医学研究室,北京100850 [2]解放军第309医院烧伤整形科,北京100091

出　　处：《生物技术通讯》2015年第2期268-271,共4页Letters in Biotechnology

基　　金：国家自然科学基金(31171342;31270797);国家重点基础研究发展计划(2011CB503803)

摘　　要：IKK复合物由IKKα、IKKβ和IKKγ组成,是NF-κB通路中的重要分子,主要调控NF-κB通路的活化。近年的研究发现,IKK复合物还存在许多NF-κB非相关性的功能,主要涉及肿瘤发生、应激反应、转录调控、免疫功能及细胞周期调控等方面。IKK复合物的NF-κB非相关性的功能研究集中于IKKα和IKKβ亚基,并且存在激酶活性依赖和非依赖2种作用方式。对于该功能的深入探讨,对全面理解IKK分子的生理病理功能十分重要,并且为IKK分子的研究提出了一个新的方向。IKK complex is responsible for regulating the activation of NF-κB, which contains three subunits, IKKα, IKKβ and IKKγ. Besides involving in NF-κB transactivation, IKK has many NF-κB-independent functions which are related to tumorigenesis, stress response, transcriptional regulation, immune functions, and cell cycle regulation. The investigations on NF-κB-independent functions of IKK focus on IKKα and IKKβ, and involving both kinase-dependent and -independent role of these components. The further investigations on this issue are important for understanding the physiological and pathological functions of IKK, which might constitute a new research area.

关 键 词：IKK复合物 NF-κB非相关性 IKKα IKKΒ 

分 类 号：Q25[生物学—细胞生物学]