Novel drug-delivery approaches to the blood-brain barrier  

作　　者：Xiaoqing Wang Xiaowen Yu William Vaughan Mingyuan Liu Yangtai Guan 

机构地区：[1]Department of Neurology, Changhai Hospital, Second Military Medical University [2]Stem Cells and Medical Research Center, Second Military Medical University [3]Department of Gerontology, Changhai Hospital, Second Military Medical University [4]Department of Genetics, Yale University

出　　处：《Neuroscience Bulletin》2015年第2期257-264,共8页神经科学通报（英文版）

基　　金：supported by the National Natural Science Foundations of China (81200924 and 81230027);the Natural Science Foundation of Shanghai Municipality, China (12ZR1427400);the Key Scientific Research Project of Shanghai Municipality, China (11411950300);the Youth Fund of the Shanghai Health Bureau, China (2011);the Innovation Research Program, Second Military Medical University, China (SCMRC1403 and SCMRC1410)

摘　　要：The blood-brain barrier （BBB） maintains homeostasis by blocking toxic molecules from the circulation, but drugs are blocked at the same time. When the dose is increased to enhance the drug concentration in the central nervous system, there are side-effects on peripheral organs. In recent years, genetic therapeutic agents and small molecules have been used in various strategies to penetrate the BBB while minimizing the damage to systemic organs. In this review, we describe several representative methods to circumvent or cross the BBB, including chemical and physical strategies.The blood-brain barrier （BBB） maintains homeostasis by blocking toxic molecules from the circulation, but drugs are blocked at the same time. When the dose is increased to enhance the drug concentration in the central nervous system, there are side-effects on peripheral organs. In recent years, genetic therapeutic agents and small molecules have been used in various strategies to penetrate the BBB while minimizing the damage to systemic organs. In this review, we describe several representative methods to circumvent or cross the BBB, including chemical and physical strategies.

关 键 词：drug delivery blood-brain barrier NANOPARTICLES focused ultrasound 

分 类 号：R96[医药卫生—药理学]