抗病毒免疫因子Viperin的研究进展  

Progress in Studies of Viperin,an important Cellular Antiviral Factor

作　　者：朱春辉[1,2] 汤艳东[2] 徐方[1] 周建华[2,3] 

机构地区：[1]宁夏医科大学基础医学院,银川750004 [2]中国农业科学院哈尔滨兽医研究所兽医生物技术国家重点实验室,哈尔滨150001 [3]哈药集团生物疫苗有限公司,哈尔滨150069

出　　处：《病毒学报》2015年第1期91-96,共6页Chinese Journal of Virology

基　　金：十二五重大传染病专项(2012ZX10001-008);国家自然科学基金(31070809)

摘　　要：先天免疫因子Viperin是一种功能与内质网相关的抗病毒蛋白,可被干扰素、多种病毒、细菌脂多糖(Lipopolysaccharides,LPS)和poly(I:C)等诱导表达。Viperin通过与病毒蛋白和某些细胞内蛋白的相互作用抑制病毒增殖,具有广谱抗病毒活性。在与宿主相互作用的长期进化过程中,某些病毒能够抑制细胞内Viperin的表达,逃逸其抗病毒功能。除抗病毒作用外,Viperin还具有其他一些生物学功能。近年来有关Viperin的研究,特别是在其抗病毒机理方面,进展较快,本文结合自身研究体会,就其基本特性和研究状况做一介绍。Viperin is an endoplasmic reticulum （ER）-associated protein that has been identified as an innate antiviral protein. Viperin expression can be largely upregulated by viruses, interferons, and oligonucleotides such as poly I：C and lipopolysaccharides. Viperin inhibits viral replication by interactiing with host cell proteins and several viral proteins, and disrupting the cell membrane system. It shows a broad-spectrum of antiviral activity. Some viruses have developed activities that counteract the action of viperin during a long-term period of evolution with hosts by impairing viperin expression. In addition to its antiviral effects, viperin has several other biological functions. This article review the basic characteristics of viperin and the state of current research into its antiviral effects, demonstrating the rapid progress that has been made in this field.

关 键 词：Viperin 抗病毒蛋白 细胞膜 宿主蛋白 相互作用 

分 类 号：S852.65[农业科学—基础兽医学]