人乳头瘤病毒致癌的分子机制及其VLPs疫苗研究进展  

Advances in Understanding Carcinogenetic Mechanisms of the Human Papillomavirus and Vaccines Based on Virus-like Particles

作　　者：赵志宏 王丽丽 马波 

机构地区：[1]云南沃森生物技术股份有限公司,昆明650106

出　　处：《病毒学报》2015年第2期180-186,共7页Chinese Journal of Virology

基　　金：国家高技术研究发展计划(2012AA02A404)资助

摘　　要：人乳头瘤病毒(HPV)是一种与人类多种疾病尤其是宫颈癌相关的病毒,自HPV与宫颈癌的关系被确认以来,其致病机制及感染预防一直是研究的热点。高危型人乳头瘤病毒的持续感染及早期蛋白的表达对其致病过程起重要作用;目前,针对四种主要高危型别HPV(HPV-6,-11,-16,-18)的VLPs疫苗已在全球范围内被广泛使用,本公司研制的HPV-16和-18型二价疫苗尚处于临床试验阶段。本文从HPV的基因组结构和功能,病毒致癌的分子机制及预防性疫苗的研究进展等方面做一综述。Prevention of infection by the human papillomavirus（HPV）has become a hot research topic since the relationship between the HPV and cervical cancer was confirmed.Persistent infection with HPV and early expression of proteins has an important role in the pathogenesis of cervical cancer.Vaccines that protect against four high-risk types of HPV（-6,-11,-16,-18）have been used worldwide.A bivalent vaccine（HPV-16and-18）developed by Walvax is in clinical trials.This study reviews progress in ascertainment of the structure and function of the HPV genome,the molecular mechanism of carcinogenesis,and vaccines based on virus-like particles.

关 键 词：人乳头瘤病毒 分子结构 致癌机制 病毒样颗粒疫苗 

分 类 号：R373.9[医药卫生—病原生物学]