中医辨证预防经期偏头痛发作的临床对照研究  

Controlled Clinical Trials of Traditional Chinese Medicine Syndrome Classification and Intervention in the Prophylaxis of Menstrual Migraine

作　　者：周从容 孙鸿辉[2] 

机构地区：[1]成都市妇女儿童中心医院中医科,成都610072 [2]成都中医药大学附属医院脑病科

出　　处：《华西医学》2015年第4期618-621,共4页West China Medical Journal

摘　　要：目的评价中医辨证预防经期偏头痛发作的效果及其安全性。方法 2013年1月-2014年6月将190例经期偏头痛患者按就诊顺序单双号分为2组,每组各95例。试验组予以中药复方汤剂,3 d服2剂,连续治疗30 d;对照组予以维生素B2 400 mg/次,1次/d,连续服用30 d。观察治疗前后偏头痛发作频率、程度、持续时间变化,评价预防效果。结果两组治疗后头痛发作频率、程度、持续时间均较治疗前改善(P<0.05);试验组受试者治疗后头痛持续时间的改善情况优于对照组,两者比较差异有统计学意义(P<0.05);两组均未发生严重不良反应。结论中医辨证预防经期偏头痛发作的效果及安全性良好。Objective To evaluate the efficacy and safety of traditinal Chinese Medicine（TCM） syndrome classification and intervention for the prophylaxis of menstrual migraine.Methods Patients consistent with the inclusion criteria from January 2013 to June 2014 were included in the trial.Patients were randomized by their visiting order into two groups：the experimental group was treated with Chinese traditional medicine compound decoctions（two doses for three days）,and the control group was treated with vitamin B_2（400 mg once daily）.The patients were treated for thirty days consecutively.Efficacy was assessed using the records of the frequency,duration,and severity of migraine attacks.Laboratory tests,vital signs,and adverse events were monitored.Results Both treatments led to a significant reduction in the frequency,duration,and severity of migraine attacks（P〈0.05）.TCM therapy was significantly better than vitamin B_2 for reducing the frequency and the duration of migraine（P〈0.05）.No serious adverse drug reaction was found in both groups.Conclusion TCM syndrome classification and intervention is effective and relatively safe in the prophylaxis of menstrual migraine attacks.

关 键 词：辨证 经期偏头痛 维生素 B2 半随机对照研究 

分 类 号：R277.7[医药卫生—中医学]