老年心脏瓣膜钙化与血清胰岛素样生长因子-1的相关性  

Correlation between valvular calcification and serum IGF-1 in the senile calcified valvular disease patients

作　　者：李春芝[1] 闫莉[1] 赵茜[1] 李绍冰[1] 

机构地区：[1]河北省人民医院,石家庄050051

出　　处：《临床心血管病杂志》2015年第4期425-427,共3页Journal of Clinical Cardiology

摘　　要：目的:探讨老年钙化性心脏瓣膜病患者瓣膜钙化与血清胰岛素样生长因子(IGF)-1的关系。方法:选取116例老年患者,通过超声心动图检查将患者分为主动脉瓣钙化组、二尖瓣钙化组、联合瓣膜钙化组(即主动脉瓣和二尖瓣均有钙化)和无瓣膜钙化组(对照组)。采用ELISA法测定血清IGF-1的浓度并进行比较。结果:主动脉瓣钙化组、二尖瓣钙化组、联合瓣膜钙化组IGF-1值分别为(281.72±71.35)pg/ml、(261.46±64.74)pg/ml、(267.84±65.13)pg/ml,明显高于对照组(137.20±43.20)pg/ml,差异有统计学意义(P<0.05),各钙化组之间差异无统计学意义(P>0.05)。IGF水平与患者血清TC、TG、LDL及年龄有明显的相关性(P<0.05)。结论:IGF-1在老年钙化性心脏瓣膜病患者血清中呈高水平表达。Objective：To explore the relationship between valvular calcification and serum concentrations of IGF-1in the senile calcified valvular disease patients.Method：One hundred and sixteen senile patients were collected.All patients were divided into four groups：aortic valve calcification（AVC）,mitral valve calcification（MVC）,allied valve calcification and normal control groups.Serum IGF-1concentrations were detected by ELISA.Result：Serum IFG-1concentrations in the group of AVC,MVC and AVC＋MVC were significantly higher than that in control group（P〈0.05）.Conclusion：Serum IGF-1concentrations increase significantly in senile patient with calcified valvular.

关 键 词：心脏瓣膜病 钙化 异位钙化 超声心动图 胰岛素样生长因子-1 

分 类 号：R542.5[医药卫生—心血管疾病]