PRGD复合神经导管修复上肢周围神经缺损  

PRGD composite nerve conduit in repair of human peripheral nerve defect in upper extremity

作　　者：黄继锋[1] 张伟才[1] 王伟莉[1] 林莉[1] 严琼姣[2] 李世普[2] 

机构地区：[1]广州军区武汉总医院,武汉430070 [2]武汉理工大学生物材料与工程研究中心

出　　处：《中华显微外科杂志》2015年第2期130-133,共4页Chinese Journal of Microsurgery

基　　金：国家“973”重点基础研究发展计划资助项目（2011CB606205）;教育部科学技术研究重大项目资助（313041）

摘　　要：目的 探讨应用PRGD复合神经导管桥接修复上肢粗大周围神经缺损的疗效. 方法 2011年12月-2014年8月,应用PRGD复合神经导管桥接修复上肢粗大周围神经缺损的患者19例,其中正中神经和桡神经各6例,尺神经7例.术后定期随访,行感觉、运动功能、高频超声及肌电图检查评估. 结果 19例患者术后均获随访,随访时间12～32（21.75±6.86）个月,根据英国医学研究会感觉、运动评价标准进行综合评价,优7例,良7例,可3例,差2例,结果优良率达73.7％. 结论 应用PRGD复合神经导管桥接修复上肢粗大周围神经缺损具有良好的疗效,为其进一步临床应用奠定了基础。Objective To explore the clinical efficacy of PRGD composite nerve conduit in the treatment of human large-diameter,critical peripheral nerve defect in upper extremity.Methods From December,2011 to August,2014,19 patients with large-diameter,critical peripheral nerve defect in upper extremity were treated with PRGD composite nerve conduit.The patients were followeded-up periodically.The sensory and motor function recovery,high frequency ultrasound,and EMG were employed to assess the efficacy.Results The patients were followed up for an average time of 12-32 months（mean 21.75 ± 6.86 months）,sensory and motor function recovered excellent in 7 patients,satisfactory in 7 patients,tolerable in 3 patients and no improvement in 2 patients were obtained according to the peripheral nerve function assessment standard built by British medical research council,the rate excellent and satisfactory results was 73.7%.Conclusion It is clinically promising to use PRGD composite nerve conduit to repair large-diameter,critical peripheral nerve defect in upper extremity,thus laying a foundation for its further application in clinical practice.

关 键 词：神经导管 周围神经缺损 修复 上肢 RGD多肽接枝聚(乳酸-羟基乙酸-L-赖氨酸) 

分 类 号：R651.3[医药卫生—外科学]