左旋咪唑对频复发型成人肾病综合征58例免疫功能的影响  

The Therapeutic Efficacy of Levamisole on Frequent Relapses Nephropathy Syndrome in Adult

作　　者：徐璐[1] 沈淑琼[1] 胡玉清[1] 孙琪[1] 蔡辉[1] 龚春水[1] 梁萌[1] 

机构地区：[1]安徽医科大学解放军174临床学院肾内科,厦门361003

出　　处：《中国中西医结合肾病杂志》2015年第3期216-218,共3页Chinese Journal of Integrated Traditional and Western Nephrology

基　　金：南京军区2013年度医药卫生科研基金资助项目(No.MS088)

摘　　要：目的：观察左旋咪唑对频复发型成人肾病综合征免疫功能的影响。方法：将本院2013年1月~2014年1月起收治频复发型成人肾病综合征患者中出现免疫功能下降者58例。按入组先后顺序,单双数随机分配至治疗组（单数,加用左旋咪唑）和对照组（双数,不加用左旋咪唑）,观察期1年,分别记录两组免疫学指标（CD4^＋、CD8^＋及CD4^＋/CD8^＋）及疾病缓解、复发等情况。结果：结果：（1）在两个观察点,治疗组患者各免疫指标均较治疗前好转（P〈0.05）,而对照组患者治疗前后免疫学指标变化差异无统计学意义（P〉0.05）。6个月时,治疗组CD4^＋比例及CD4^＋/CD8^＋比值较对照组升高,差异具有统计学意义（P〈0.05）,而CD＋8指标变化差异无统计学意义（P〉0.05）。12个月,治疗组各免疫指标均较对照组好转,差异具有统计学意义（P〈0.05）。（2）经治疗后,两组患者尿蛋白定量均较入组时减少（P〈0.05）,且治疗组减少程度较对照组大。（3）两组患者缓解率均差异无统计学意义（P〉0.05）,但治疗组完全缓解者多于对照组,两者差异具有统计学意义（P〈0.05）。（4）在两个观察点治疗组复发率均低于对照组,差异有统计学意义（P〈0.05）。结论：在出现免疫功能下降的频复发型成人肾病综合征成人患者中,加用左旋咪唑可调节患者免疫功能,有助于提高患者完全缓解率及减少复发率等作用。Objective： Investigate the influence on the therapeutic efficacy of levamisole on frequent relapses nephropathy syndrome in adult. Methods： We take 58 frequent relapses nephrotic syndrome patients who appear decreased immune function during Jan. 2013 to Jan. 2014 for the research. They were divided into treatment group（ odd,using levamisole） and control group（ even,without using levamisole）. During one year observation period,two groups of immunological index（ CD4^＋,CD8^＋,CD4^＋/ CD8^＋）,disease recurrence,infection,urine protein were recorded. Results：（ 1） Two observation points,immunology index of treatment group was better than those of control group（ P〈0. 05）,and in control group,the immunology index remains significant unchanged（ P〉0. 05）. At six months,contrast with control group,the treatment group CD4^＋and CD4^＋/ CD8^＋increases,CD＋8has no Statistical differences（ P〉0. 05）. At twelve months,the immunology index of the treatment group was better than that of control group,has statistical differences（ P〈0. 05）.（ 2） Both groups urinary protein went down after treatment（ P〈0. 05）. The treatment group decrease more than the control group.（ 3） The remission rate of both groups had no statistical differences（ P〈0. 05）,but the completed remission patients in treatment group were more than those in control group. They had statistical differences（ P〈0. 05）.（ 4） Disease recurrences in treatment group were lower than those of control group（ P〈0. 05）. Conclusion： To requent relapses syndrome of patients who decreased immune function,treatment of levamisole enhanced their immune function,increased remission rate,and decreased urine protein,therefore reduced recurrence rate.

关 键 词：左旋咪唑 频复发型肾病综合征 

分 类 号：R692[医药卫生—泌尿科学]