丹参水提物对乳鼠心肌细胞缺氧-复氧损伤的保护作用  

Protective effect by Salvia Miltiorrhiza aqueous extract for hypoxia-reoxygenation damage in myocardial cells of suckling mice

作　　者：张东涛[1] 黄伟哲[2] 陈喜珊[3] 

机构地区：[1]汕头大学医学院第一附属医院心血管内科,515041 [2]汕头大学医学院第一附属医院心胸外科,515041 [3]汕头大学医学院第二附属医院心血管外科

出　　处：《中国实用医药》2015年第7期284-285,共2页China Practical Medicine

摘　　要：本文研究丹参水提物对乳鼠心肌细胞缺氧-复氧损伤的保护作用。以乳鼠心室肌进行心肌细胞培养并建立缺氧-复氧损伤模型,检测不同浓度丹参水提物预处理后细胞的存活率,乳酸脱氢酶(LDH)、肌酸激酶(CK)、天冬氨酸转移酶(AST)的泄漏量及Akt的磷酸化水平。丹参水提物对缺氧-复氧损伤的心肌细胞具有明显的保护作用,这可能与它激活PI3K/Akt信号通路有关。To study the protective effect by Salvia Miltiorrhiza aqueous extract for hypoxia-reoxygenation damage in myocardial cells of suckling mice. The hypoxia-reoxygenation damage model was made from myocardial cells culture of suckling mice. Detection was taken on cells survival rate, leakage rates of lactate dehydrogenase（LDH）, creatine kinase（CK）, aspartate transaminase（AST）, and phosphorylation level of Akt of cells in different concentrations of Salvia Miltiorrhiza aqueous extract. Salvia Miltiorrhiza aqueous extract provides obviously protective effect for myocardial cells with hypoxia-reoxygenation damage, and that may be related with its activation of PI3K/Akt signal path.

关 键 词：缺氧-复氧 心肌细胞 丹参水提物 

分 类 号：R285.5[医药卫生—中药学]