远志汤药物制备物的质量表征及其关联分析  

Quality characteristics and correlation analysis of medicinal preparations from Yuanzhi Tang

作　　者：张璐[1] 李焕娟 潘婷[1] 杨元[1] 许舒娅[1] 陈唯[1] 彭平[1] 石任兵[1,2] 

机构地区：[1]北京中医药大学中药学院国家中医药管理局中药经典名方有效物质发现重点实验室,硕士研究生100102 [2]北京市教委中药质量控制技术工程中心

出　　处：《环球中医药》2015年第3期260-265,共6页Global Traditional Chinese Medicine

基　　金：国家"十二五"科技支撑计划(2012BAI29B06);北京中医药大学科研创新团队资助项目(2011-CXTD-12);北京中医药大学重点学科开放课题(2013-2DXKKF-23)

摘　　要：目的优选远志汤的最佳药物制备物形式,为创制优质抗抑郁药物奠定基础。方法以药物体系为基础,采用所建立的分析法测定远志汤有效指标性成分的含量。基于含量、含量相对比值、相对量、出膏率以及抗抑郁药效,对其质量进行系统表征,并关联分析。结果三种远志汤药物制备物均表现出抗抑郁作用,远志汤富集物有效指标性成分含量高、出膏率低、用量小且抗抑郁作用强,为抗抑郁的最佳药物制备物形式。结论基于药物体系的基本组成与制备得率,关联药学—药效分析得出,提高有效指标性成分的含量,优化组成比例,是创制优质药物的重要途径。Objective To find out what are key factors influencing the quality Yuanzhi Tang and create quality antidepressant drug foundation. Methods The content of effective index components of medicinal-preparation of Yuanzhi Tang was detected by using HPLC-PDA based on determination of party preparation Yuanzhi Tang. The quality of medicinal preparation from Yuanzhi Tang were characterized based on the content, relative quantity, relative ratio of content, yield rate and antidepressant effect, and the characterized results were given correlation analysis. Results All three kinds of medicinal-preparation had antidepressant effects,. According to the medicine-efficacy correlation analysis, the content of effective in-dex components is higher in enrichment , lower extraction rate, lower dosage and higher antidepressant effect, which is the best medicinal-preparation application form of Yuanzhi Tang. Conclusion Based on the basic composition and extraction rate of medicinal system, the key factor for increasing medicinal efficacy is to promoting relative effective components and optimizing their proportion.

关 键 词：远志汤 药物体系 质量表征 关联分析 

分 类 号：R284.1[医药卫生—中药学]