基于药物体系质量评价模式的白芷质量表征关联分析研究  

Quality characterization and correlation analysis of Baizhi( Angelica Dahurica) based on a new quality evaluation model of drug system

作　　者：孙雅姝 张璐[1] 潘婷[1] 温静[2] 迟蕾[1] 黄亚婷[1] 李焕娟 孙道涵[1] 姜艳艳[1,3] 石任兵 

机构地区：[1]北京中医药大学中药学院国家中医药管理局中药经典名方有效物质发现重点实验室,硕士研究生100102 [2]首都医科大学中医药学院 [3]北京市教委中药质量控制技术工程中心

出　　处：《环球中医药》2015年第3期266-273,共8页Global Traditional Chinese Medicine

基　　金：国家"十二五"科技支撑计划(2012BAI29B06);北京中医药大学科研创新团队资助项目(2011-CXTD-12);北京中医药大学重点学科开放课题(2013-2DXKKF-23)

摘　　要：目的应用药物体系质量评价模式,对基于药物体系的白芷中各有效指标性成分进行含量测定并进行关联分析,全面表征与评价白芷质量。方法采用HPLC-PDA法对白芷中绿原酸、花椒毒酚、佛手柑内酯、欧前胡素、异欧前胡素等5种有效指标性成分的含量进行同时测定。结果基于药物体系质量评价模式,对白芷中有效指标性成分含量及其相对比值进行质量表征,同时将不同批次饮片与经过药效验证的基准批次饮片进行关联度分析。结果表明,批次2、3、13、17、21中有效指标性成分含量总体高于基准批次饮片20,批次1、5、9、11、22、24中有效指标性成分含量与批次20接近,批次5、11、1、24、9、3、13、19与批次20质量关联度较高。综合质量表征及关联分析结果,批次3、13、2、17、21、1、5、9、11、22、24质量优良度位于前列。结论基于药物体系质量评价模式,以具有确切药效的白芷饮片为基准,对白芷质量进行关联分析研究,可全面地评价白芷饮片质量,优选白芷资源。Objective Based on quality evaluation model of drug system, to determine the content and analyze correlation of effective index components in drug system of Baizhi（ Angelica dahurica） , for the comprehensive quality of characterization and evaluation of angelica dahurica. Methods Use HPLC-PDA method for simultaneous determination of 5 effective index components in twenty-four numbers of Baizhi （ Angelica dahurica） , including Chlorogenic acid, Xanthotol, Bergapten, Imperatorin and Isoimperatorin. Results Based on quality characterization model of drug system, to represent quality based on the content and the content relative ratio of effective index components and analyze correlation between the reference which its therapeutic effect has been identified and other samples. The result shows the total content of effective index components in No. 2, No. 3, No. 13, No. 17 and No. 21 are higher than No. 20, and No. 1, No. 5, No. 9, No. 11, No. 22 and No. 24 are closer to No. 20. Compared with No. 20, the correlation degree of quality representation of No. 5, No. 11, No. 1, No. 24, No. 9, No. 3, No. 13, No. 19 is higher.＆amp;nbsp;Consolidated quality characterization and correlation analysis, the quality of No. 3, No. 13, No. 2, No. 17, No. 21, No. 1, No. 5, No. 9, No. 11, No. 22 and No. 24 are excellent. Conclusion Using quality evaluation model based on drug system, and with the exact therapeutic effect Angelica dahurica slices as a benchmark, for correlation analysis of quality research of Angelica dahurica which can comprehensively evaluate the quality of Angelica dahurica yinpian, providing the basis for looking for resources of Angelica dahurica .

关 键 词：白芷 绿原酸 花椒毒酚 佛手柑内酯 欧前胡素 异欧前胡素 质量评价 关联分析 

分 类 号：R284.1[医药卫生—中药学]