血管中血栓流动及其影响的数值模拟  

Numerical simulation of the thrombus flow and its influences in blood vessels

作　　者：吴云[1] 王妍[2] 余亚杰 许松林[2] 

机构地区：[1]天津市南开区王顶堤医院内科,天津300190 [2]天津大学化工学院制药工程系,系统生物工程教育部重点实验室,天津300072

出　　处：《天津医科大学学报》2015年第2期109-112,120,共5页Journal of Tianjin Medical University

基　　金：国家自然科学基金资助项目(21176170)

摘　　要：目的:研究血液流动模式的改变对血栓形成的影响,分析血栓的存在对血管壁的压力和壁面剪切力造成影响的程度。方法:采用计算流体力学软件建立简化的2D血管模型,对血管中血栓和血液的两相流动进行数值模拟,研究血栓随血液流动的规律以及血栓大小、阻塞率及其不同存在形式对血管壁的影响,并对易产生血栓的部位进行分析预测。结果:血栓的大小和存在形式在流动上存在一定的差异,且与血液流动速度有关。结论:血栓的存在会导致血管壁的压力和壁面剪切力上升,从而对血管壁内膜造成损伤;血栓易形成于阻塞部位附近的低速区,阻塞率越大,血栓形成风险越大。Objective：To study the effect of the blood flow patterns change on thrombus formation; and to study the impact of presence of thrombus on the vascular wall pressure and the wall shear stress. Methods： Computational fluid dynamics（CFD） software was used to establish simplified 2D vessel models, and the two-phase flow of blood and thrombus was simulated to study the rules of the thrombus flow as well as the influence of the size, and the influencethe blocking rate and different forms of thrombus on the vascular wall. Furthermore, the regions prone to thrombus formation were analyzed and predicted. Results： Research showed that the flow pattern of different presence forms and sizes of thrombus varied, and it was related to blood flow rate. Conclusion： Presence of thrombus can lead to pressure change and increased wall shear stress, causing damage to the vascular intimal. Thrombus in the low-speed regions near the site of the blockage are likely to form and the risk of thrombus formation is higher with the increasing of occlusion rate.

关 键 词：血栓 血液流动 壁面压强 壁面剪切力 

分 类 号：R318[医药卫生—生物医学工程]