降钙素原和C反应蛋白诊断尿脓毒症的价值  

Value of procalcitonin and C reactive protein in diagnosis of urosepsis

作　　者：张成龙[1] 郇娟[1] 师伟[1] 韩双羽 王哲[1] 郭文学[1] 贾宇驰 王玉宝[1] 

机构地区：[1]天津医科大学第二医院感染性疾病研究所,天津300211

出　　处：《天津医科大学学报》2015年第2期147-149,共3页Journal of Tianjin Medical University

摘　　要：目的：探讨降钙素原（PCT）和C反应蛋白（CRP）对尿脓毒症的诊断价值。方法：将102例符合纳入标准的泌尿系感染患者分为尿脓毒症组和非尿脓毒症组,比较尿脓毒症和非尿脓毒症患者血清PCT和CRP之间的差异,并绘制PCT和CRP诊断尿脓毒症的受试者工作曲线（ROC）。结果：102例泌尿系感染患者中,尿脓毒症患者43例,非尿脓毒症患者59例;尿脓毒症组PCT、CRP显著高于非尿脓毒症组（P均〈0.001）;PCT、CRP在尿脓毒症的ROC曲线下面积分别是0.759、0.710（95%置信区间0.608~0.811、0.666~0.851）,在各自最佳工作位点,PCT和CRP诊断尿脓毒症的敏感性分别是0.907和0.419,特异性分别是0.610和0.932,阳性预测值分别是0.629和0.818,阴性预测值分别是0.900和0.688。结论：PCT和CRP是诊断尿脓毒症的良好指标。Objective：To investigate the roles of procalcitonin（PCT） and C-reactive protein（CRP） serum concentrations in the diagnose of urosepsis. Methods：One hundred and two patients with uriary tract infection（UTI） were divided into urosepsis group and non-urosepsis group. The PCT and CRP serum concentrations were compared between urosepsis group and non-urosepsis group, and the receiver operating characteristic（ROC） curves were constructed. Results： Forty-three patients were with urosepsis and 59 patients were without urosepsis. Compared with the non-urosepsis group, the serum concentrations of PCT and CRP increased significantly in the urosepsis group（P0.001）. The area under ROC curve of PCT and CRP diagnosing urosepsis were 0.759（95%CI：0.608~0.811） and 0.710（95% CI： 0.666~0.851）,respectively. At the optimal operating points, the sensitivity, specificity, positive predictive value and negative predictive value of PCT and CRP diagnosing urosepsis were 0.907, 0.419, 0.610, 0.932, 0.629, 0.818, 0.900 and 0.688 respectively. Conclusion：PCT and CRP are effective biomarkers for urosepsis.

关 键 词：尿脓毒症 泌尿系感染 降钙素原 C反应蛋白 ROC曲线 

分 类 号：R631[医药卫生—外科学]