Prevalence and Prescription of Antidepressants in Depression with Somatic Comorbidity in Asia： The Research on East Asian Psychotropic Prescription Patterns Study  

作　　者：Chao Chen Tian-Mei Si Yu-Tao Xiang Gabor S Ungvari Chuan-Yue Wang Yan-Ling He Ee-Heok Kua Senta Fuji Kang Sim Jitendra K Trivedi Eun-Kee Chung Pichet Udomratn Kok-Yoon Chee Norman Sartorius Chay-Hoon Tan Naotaka Shinfuku 

机构地区：[1]Key Laboratory of Mental Health, Ministry of Mental Health and Peking University Institute of Mental Health, Beijing 100083, China [2]Faculty of Health Sciences, University of Macao, Macao SAR, China [3]Department of Psychiatry, Chinese University of Hong Kong, Hong Kong SAR, China [4]School of Psychiatry and Clinical Neurosciences, University of Western Australia, Perth, Australia [5]Beijing Anding Hospital, Capital Medical University, Beijing 100088, China [6]Shanghai Mental Health Center, Shanghai 200030, China [7]Department of Psychological Medicine, National University of Singapore, Singapore [8]Department of Disaster Psychiatry, Fukushima Medical University, Fukushima, Japan [9]Institute of Mental Health, Buangkok View, Singapore [10]Department of Psychiatry, C.SM. Medical University, Lucknow, Uttar Pradesh, India [11]Department of Psychiatry, National Seoul Hospital, Seoul, Korea [12]Department of Psychiatry, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand [13]Department of Psychiatry and Mental Health, Tunku Abdul Rahman Institute of Neuroscience, Kuala Lumpur Hospital, Kuala Lumpur, Malaysia [14]Association for the Improvement of Mental Health Programs, Geneva, Switzerland [15]Department of Pharmacology, National University of Singapore, Singapore [16]School of Human Sciences, Seinan Gakuin University Fukuoka, Fukuoka, Japan

出　　处：《Chinese Medical Journal》2015年第7期853-858,共6页中华医学杂志（英文版）

摘　　要：Background： Depression is often comorbid with chronic somatic diseases. Few previous studies have investigated the prevalence of somatic diseases in depression or the prescription pattern of antidepressants in comorbidly depressed patients in Asia. This study aimed to investigate the prevalence of somatic comorbidity （SC） in depression and compared the prescriptions of antidepressants in depressed patients with and without SC. Methods： A total of 2320 patients treated with antidepressants in 8 Asian countries were examined, and a diagnosis was based on the International Classification of Disease, 10^th revision. We listed 17 common chronic somatic diseases. Patients＇ socio-demographic and clinical characteristics and psychotropic drug prescriptions were recorded using a standardized protocol and data collection procedure. Results： Of the patients examined, 1240 were diagnosed with depression and 30% of them （n = 375） had SC. The most common comorbid condition was diabetes （23.7%）. The patients with SC were more likely to seek help at a general hospital （74.7% vs. 47.2%）, and had a higher incidence of symptoms involving sadness, disturbed sleep, and poor appetite. Noradrenergic and specific serotonergic antidepressant was prescribed more for patients with SC than for those without SC （30.4% vs, 22.9%）. Conclusions： SC is common in depressed Asian patients. It is important to strengthen the recognition of depression, especially in general hospitals and when patients report some somatic discomfort. It is also a matter of urgency to establish evidence-based guidelines for the use of new antidepressants in depressed patients with SC.Background： Depression is often comorbid with chronic somatic diseases. Few previous studies have investigated the prevalence of somatic diseases in depression or the prescription pattern of antidepressants in comorbidly depressed patients in Asia. This study aimed to investigate the prevalence of somatic comorbidity （SC） in depression and compared the prescriptions of antidepressants in depressed patients with and without SC. Methods： A total of 2320 patients treated with antidepressants in 8 Asian countries were examined, and a diagnosis was based on the International Classification of Disease, 10^th revision. We listed 17 common chronic somatic diseases. Patients＇ socio-demographic and clinical characteristics and psychotropic drug prescriptions were recorded using a standardized protocol and data collection procedure. Results： Of the patients examined, 1240 were diagnosed with depression and 30% of them （n = 375） had SC. The most common comorbid condition was diabetes （23.7%）. The patients with SC were more likely to seek help at a general hospital （74.7% vs. 47.2%）, and had a higher incidence of symptoms involving sadness, disturbed sleep, and poor appetite. Noradrenergic and specific serotonergic antidepressant was prescribed more for patients with SC than for those without SC （30.4% vs, 22.9%）. Conclusions： SC is common in depressed Asian patients. It is important to strengthen the recognition of depression, especially in general hospitals and when patients report some somatic discomfort. It is also a matter of urgency to establish evidence-based guidelines for the use of new antidepressants in depressed patients with SC.

关 键 词：ASIA DEPRESSION PRESCRIPTION PREVALENCE Somatic Comorbidity 

分 类 号：S858.23[农业科学—临床兽医学] TQ463[农业科学—兽医学]