老年冠心病患者胃癌根治术中七氟醚和丙泊酚麻醉的心肌保护作用对比  

Comparative study of cardioprotective effect of sevoflurane and propofol anesthesia in elderly patients with coronary heart disease during radical gastrectomy

作　　者：尤华[1] 谢灿果[2] 

机构地区：[1]随州市中心医院麻醉科,441300 [2]随州市中心医院呼吸内科,441300

出　　处：《国际医药卫生导报》2015年第8期1060-1062,共3页International Medicine and Health Guidance News

摘　　要：目的探析老年冠心病患者胃癌根治术中七氟醚与丙泊酚麻醉的心肌保护作用。方法入选2013年3月至2014年3月我院冠心病合并胃癌老年患者86例，所有患者均进行胃癌根治术，按麻醉方式的不同分为实验组和对照组，实验组进行七氟醚复合瑞芬太尼麻醉，对照组进行丙泊酚复合瑞芬太尼麻醉，比较两组患者不同时间点的血清肌酸激酶同工酶（CK—MB）及血清心肌肌钙蛋白I（eTnI）水平。结果实验组患者术后6、12、24h的CK—MB、eTnI水平显著低于对照组，差异有统计学意义（P〈0．01）。结论老年冠心病患者胃癌根治术进行七氟醚与瑞芬太尼复合麻醉保护心肌效果更强，值得临床推广。Objective To compare eardioprotective effect of sevoflurane and propofol anesthesia in elderly patients with coronary heart disease during radical gastrectomy. Methods 86 elderly patients with gastric cancer and coronary heart disease were selected in our hospital from March 2013 to March 2014. All patients underwent radical gastrectomy, and were divided into experimental group and control group according to different anesthesia methods. Experimental group underwent sevofiurane combined with remifentanil anesthesia, while control group underwent propofol combined with remifentanil anesthesia. Compared levels of serum creatine kinase isoenzyme （CK-MB） and cardiac troponin I （cTnl） at different time points of two groups. Result The levels of CK-MB, cTnI 6, 12, 24 hours after operation in experimental group were significantly lower than those in control group, with statistically significant differences （P〈0.01）. Conclusion Cardioprotective effect of sevoflurane combined with remifentanil anesthesia is much stronger in elderly patients with coronary heart disease during radical gastrectomy, worthy of clinical promotion.

关 键 词：心肌保护 老年冠心病 丙泊酚 七氟醚 

分 类 号：R541.4[医药卫生—心血管疾病]