2型糖尿病肾病与胃肌电活动的临床研究  

The Clinical Study of Nephropathy and Gastric Electrical Activity in Type 2 Diabetic Mellitus

作　　者：孙敏娴[1] 赵湜[1] 王中京[1] 程晨[1] 

机构地区：[1]武汉市中心医院内分泌科,湖北武汉430000

出　　处：《中国医学装备》2014年第B08期181-182,共2页China Medical Equipment

摘　　要：目的：观察不同阶段的2型糖尿病肾病患者24h尿白蛋白、消化系统症状、胃电图参数等临床情况，分析糖尿病肾病患者胃肌电活动的特点。方法：将60例2型糖尿痛患者根据24h尿白蛋白定量分为A组（〈30mg／24hr，18例）、B组（30-300mg／24hr，20例）、C组（〉300mg／24hr，22例），观察其消化道症状及一般情况，行餐前、餐后胃电图检查，对胃电活动等参数进行统计分析。结果：A、B、C三组上消化系统症状评分分别为O．44±0.511、115±O．813、127±O.703．上消化道症状出现的例数分别为27．8％、75.0％、90.9％，P、PA-C〈005糖尿病组胃窦DF均低于对照组。组间比较DF：A组〉B组〉c组，其中昂日〈O．05。餐前／餐后功率比（PR）对照组〉A组〉B组〉c组，组间比较均有统计学差异（P〈0.05），其中对照组与A组大于1，B组和C组小于1。结论：2型糖尿病肾病早期，虽无明显消化道症状，但可能已伴有胃肌电活动异常。出现上消化道症状或尿蛋白增高的2型糖尿病患者需警惕糖尿病胃轻瘫的发生。Objective： To observe the clinical conditions in the different stages of the type 2 diabetic patients with nephropathy, including 24 hours urine albumin concentrations, symptoms of digestive system, and electrogastrogram parameters, in order to analyze the characteristics of the gastric electrical activity of them. Methods 60 patients with type 2 diabetic mellitus were divided into 3 groups, according to 24 hours urine albumin concentrations： group A（〈30mg/24hr, n=18）, B（30~300mg/24hr, n=20） and C（〉300mg/24hr, n=22）. We observed their digestive symptoms, other clinical conditions, and parameters recorded by fasting and postprandial electrogastrogram test. Results： The average scores of digestive symptoms in group A, B and C were 0.44±0.511,1.15±0.813 and 1.27±0.703 respectively, while the percentage were 27.8%,75.0% and 90.0%, P（A-B） P（A-C）〈0.05 Compared with the control group, N% in sinuses ventriculi of group A, B, C and in body stomach of group C were significantly lower. DF in sinuses ventriculi of the 3 groups and DF in body stomach of group C were lower than control group, P〈0.05.The conditions of DF compared in 3 groups were A〉B〉C, while P（A-C）〈 0.05. Postprandial to fasting power mtio both in body of stomach and sinuses ventrieuli were found significant differences between group A,B,C and control group,control group〉A〉B〉C, while the PR of the former 2 groups were more than 1,and the latter 2 groups were less than 1. Conclusions： Patients with type 2 diabetic mellitus may present no obvious digestive symptoms in the early stage of nephropathy, but may have been complicated with abnormal gastric electrical activity. Early examination and regulation of their therapy should be considered.

关 键 词：2型糖尿病 糖尿病肾病 糖尿病胃轻瘫 胃电活动 胃电图 

分 类 号：R587.1[医药卫生—内分泌]