姜黄素明胶微球在大鼠体内靶向性研究  

Targeting Effect of Curcumin Gelatin Microspheres in Rats in vivo

作　　者：邓俊刚[1] 陈薇[1] 黄桂红[1] 李江[1] 邓航[1] 

机构地区：[1]桂林医学院附属医院药学部,桂林541001

出　　处：《医药导报》2015年第4期445-447,共3页Herald of Medicine

基　　金：广西科学研究与技术开发计划项目(桂科攻0999003);广西医疗卫生重点科研课题(重2010054)

摘　　要：目的研究肺靶向姜黄素明胶微球在大鼠体内的器官靶向性。方法分别尾静脉给予大鼠姜黄素明胶微球和姜黄素注射液,高效液相色谱法测定各器官姜黄素含量,采用DAS2.0版软件计算药动学参数,用靶向效率来评价其在大鼠体内的组织分布及靶向性。结果姜黄素明胶微球在心、肝、脾、肺、肾的靶向效率分别为0.875,0.121,1.182,5.834,0.896。结论姜黄素明胶微球具有很好的肺靶向作用,有利于药物的肺靶向治疗研究。Objective To observe the targeting effect of curcumin gelatin microsphere in rats in vivo. Methods Injections of curcumin gelatin microsphere and curcumin were injected via tail vein, respectively. HPLC was used to determine the content of curcumin in different organs. The pharmacokinetic parameters were calculated on the basis of compartment models by using DAS 2. 0 program. Targeting efficiency was used to evaluate tissue distribution of curcumin. Results Targeting efficiency of curcumin gelatin microsphere in heart, liver, spleen, lung and kidney was 0. 875, 0. 121, 1. 182, 5. 834 and 0. 896, respectively. Conclusion Curcumine gelatin microspheres can improve lung-targeting efficiency, and benefit for study on lung targeting therapeutic effect.

关 键 词：姜黄素 明胶微球 靶向率 

分 类 号：R282[医药卫生—中药学] R285.5[医药卫生—中医学]