魔芋胶-丹皮酚骨架片处方优化  

Optimization of the Formula of Konjac Glucomannan-Paeonol Matrix Tablets

作　　者：揭晶[1] 聂淑芳[1] 杨波[1] 赖晓晶[1] 刘冬琳[1] 

机构地区：[1]武汉生物工程学院药学院,武汉430415

出　　处：《医药导报》2015年第4期502-505,共4页Herald of Medicine

基　　金：国家自然科学基金资助项目(31302144);湖北省自然科学基金资助项目(2012FFB05201);武汉市青年科技晨光计划项目(201150431085);湖北省高等学校青年教师深入企业行动计划项目(XD2012501)

摘　　要：目的优化魔芋胶-丹皮酚骨架片的处方。方法采用正交实验设计,以体外累积释放度为指标,考察魔芋胶(KGM)的黏度、KGM和乳糖的用量3个影响因素,筛选对KGM-丹皮酚骨架片的最佳处方。结果最佳处方为KGM的黏度为20 000 m Pa·s,KGM 30%,乳糖20%,体外释放度实验表明其体外释药符合Higuchi方程。结论 KGM-丹皮酚骨架片处方合理,具有良好的体外缓释效果。Objective To optimize the formula of konjac glucomannan-paeonol matrix tablets. Methods The formula of paeonol matrix tablets was optimized by the orthogonal design with the accumulative release rate in vitro as index, with the viscosity of konjac glucomannan （KGM）, the amount of KGM and lactose as influence factors. Results The optimized formula was as follows ： the viscosity of konjac glucomannan was 20 000 mPa · s, KGM 30% , lactose 20% and the release in vitro fit into the Higucbi equation. Conclusion The formula of the paeonol matrix tablets is reasonable and the tablets have well release effect in vitro.

关 键 词：魔芋胶-丹皮酚 骨架片 处方优化 释放度 累积 正交实验 

分 类 号：R286[医药卫生—中药学] R927.2[医药卫生—中医学]