铁调素及其与骨代谢的研究进展  

Advance in the research of hepcidin and its role in bone metabolism

作　　者：张千依 郭婧芳[1] 唐冠群[1] 朱宪春[1] 

机构地区：[1]吉林大学口腔医院正畸科,吉林长春130021

出　　处：《口腔医学》2015年第4期314-317,共4页Stomatology

基　　金：吉林省卫生厅科研计划项目(2013Z053)

摘　　要：铁调素(Hepcidin)是一类调节机体铁稳态的抗菌多肽,由HAMP基因编码,大量研究表明血清中铁的含量、骨形成蛋白(BMPs)、白介素-6(IL-6)及低氧诱导因子(HIF)等可调控铁调素的表达;最新研究表明其与骨代谢相关,铁调素可通过"铁调素-铁代谢-骨代谢"和"JAK/STAT"信号通路这两种途径影响骨代谢。该文就铁调素的生成机制及其在骨代谢中作用的相关研究进行综述。Hepcidin is a kind of antimicrobial peptide regulating organic iron homeostasis,and it is encoded by HAMP gene. Concerning the generating mechanism of hepcidin,the content of serum iron,bone morphogenetic proteins（BMPs）,interleukin-6（IL-6）,hypoxia-inducible factor（HIF） or other signaling factors can regulate its expression. The latest study indicates that hepcidin is involved in bone metabolism. It affects bone metabolism process through the ＂hepcidin-iron metabolism-bone metabolism＂and ＂JAK/STAT＂signaling pathway. This articlereviews relevant researchesofhepcidin generation mechanism and its relationship with bonemetabolism.

关 键 词：铁调素 骨代谢 骨形成蛋白 “JAK/STAT”信号通路 

分 类 号：R341.8[医药卫生—基础医学]