健康人群W135群脑膜炎奈瑟菌免疫水平研究  

A study on the immunity level of Neisseria meningitides serogroup W135 among healthy population

作　　者：陈深侠[1] 谢锦荣 赵中飞[1] 陈恩富[2] 张政[2] 

机构地区：[1]诸暨市疾病预防控制中心,浙江诸暨311800 [2]浙江省疾病预防控制中心

出　　处：《浙江预防医学》2015年第4期325-327,333,共4页Zhejiang Journal of Preventive Medicine

基　　金：浙江省医药卫生平台重点资助计划项目(2012ZDA008)

摘　　要：目的调查健康人群W135群脑膜炎奈瑟菌免疫水平,为制定含W135群流脑疫苗免疫程序提供依据。方法2011年在诸暨市按东西南北中选择5个乡镇/街道,分层随机抽取410名0~14岁无流脑病史和免疫史的本地健康儿童及同乡镇≥15岁健康居民并采集血样,用ELISA法检测W135群脑膜炎奈瑟菌多糖抗体（Ig G）浓度,Ig G浓度≥2μg/m L为阳性。结果 410名儿童W135群脑膜炎奈瑟菌抗体平均浓度为（1.46±0.25）μg/m L,抗体阳性率为4.63%。儿童W135群脑膜炎奈瑟菌抗体浓度及阳性率在地区、性别差异均无统计学意义（P〉0.05）。儿童各年龄组间抗体平均浓度差异有统计学意义（P〈0.05）。15岁~组抗体浓度（1.63±0.28）μg/m L高于其他年龄组（P〈0.05）;1.5岁~组抗体浓度（1.37±0.19）μg/m L低于5岁~组（1.55±0.29）μg/m L（P〈0.05）,与0岁~组（1.50±0.25）μg/m L比较差异无统计学意义（P〉0.05）;60岁~组抗体浓度（1.29±0.20）μg/m L低于0岁~和5岁~组（P〈0.05）。结论健康儿童的W135群脑膜炎奈瑟菌免疫水平普遍较低,建议在适当的年龄开展含W135群流脑疫苗接种。Objective To learn the immunity level of Neisseria meningitides（ Nm） serogroup W135 among healthy population. Methods A total of 410 children aged 0- 14 years were selected by stratified random sampling method in Zhuji city. The polysaccharide antibody Ig G level of Nm serogroup W135 was detected by ELISA. The antibody concentrations more than 2 μg / m L were identified as positive. Results The geometric mean concentration（ GMC） was 1. 46 ± 0. 25 μg / m L and the W135- antibody positive rate was 4. 63%. There was no difference on antibody GMC and the W135- antibody postive rate among different region and gender groups. There were statistical differences on antibody GMC among different age groups（ P〈0. 05）. The antibody GMT in the age group 15- 34（ 1. 63 ± 0. 28 μg / m L） was significantly higher than that in other age groups（ P〈0. 05）,and the antibody GMT in the age group 1. 5- 4（ 1. 37 ± 0. 19 μg / m L） was significantly lower than that in the age group 5- 14（ P〈0. 05）. The antibody GMT were significantly lower in the elderly（ ≥60 years old） than that in the age group 10 and 5- 14（ P〈0. 05）. Conclusion The immunity level of Nm serogroup W135 among healthy population is low,and it is suggested to be immunized by the vaccines which contained Nm W135.

关 键 词：儿童 W135群脑膜炎奈瑟菌 免疫水平 

分 类 号：R378.15[医药卫生—病原生物学]