长春市城区老年人群高尿酸血症的流行病学调查及其与心血管相关危险因素分析  

Survey of hyperuricemia and its association with the risks of cardiovascular disorders in elder people of Changchun City

作　　者：宋成伟[1] 杜以武[1] 刘颖[1] 卢颖[1] 高堃[1] 梁斌斌[1] 

机构地区：[1]吉林大学第四医院老年病科,长春130011

出　　处：《中华风湿病学杂志》2015年第4期266-269,共4页Chinese Journal of Rheumatology

摘　　要：目的 探讨长春市城区老年人群高尿酸血症（HUA）的患病率现状,以及其与心血管危险因素的相关性.方法 对长春市城区西新社区55周岁以上居民采用整群随机抽样的方法,抽取900名居民,进行问卷调查、体格检查和实验室检查,用SPSS 17.0统计分析软件,定量资料均以（x）±s的方式表示,组间比较均数采用两组独立样本t检验;定性资料以例数及百分数方式表示,组间比较采用x2检验;血尿酸水平与危险因素指标相关性分析采用x^2检验,HUA患病情况与心血管危险因素的分析采用二元非条件Logistic回归分析;尿酸水平与常见心血管危险因素的分析采用多因素线性回归分析.结果 长春市西新城区老年居民HUA患病率为16.0％（144/900）;初老组（55 ～65岁）、老龄组（66～75岁）、高龄组（76岁以上）HUA的患病率分别为13.7％（50/365）、15.2％（47/309）和20.8％（47/226）,各组间患病率差异无统计学意义（x2=4.915 1,P=0.085）;男性与女性居民间患病率的差异无统计学意义（x2=0.023 5,P＞0.05）.血压、TC、高敏（hs）-CRP及BMI、腰臀比水平不同的人群间,HUA的患病率差异有统计学意义;高尿酸组与正常尿酸组患者相比,TC（t=-38.52,P=0.001）和hs-CRP的水平（t=-24.41,P=0.003 1）差异有统计学意义,且血浆尿酸水平与TC 、TG呈正相关（r=0.364,P＜0.05;r=0.479,P＜0.05）.结论 随着年龄的增长,HUA患病率明显升高;尿酸水平升高与主要心血管危险因素之间呈正相关.HUA在高血压、高血脂及超重、肥胖者的人群中明显高发.改变不良的生活方式和合理饮食可能预防或减少HUA的发生.Objective To survey the prevalence of Hyperuricemia （HUA） in elder population of Changchun city,and to detect the correlation between cardiovascular risk factors and the HUA.Methods 900 residents older than 55 years were selected randomly for this questionnaire survey.Physical and laboratory examinations were performed.Results The HUA prevalence rate elder people in Xixin District of Changchun was 16.0%（144/900）,while the rates were 13.7%（50/365）,15.2%（47/309） and 20.8%（47/226） （P〈0.05） in the elder group （55-65 years）,the aged group （66-75 years）,and the advanced aged group （older than 76 years） respectively;there was no statistical significant difference in the prevalences between male and female （x^2=0.023 5,P〉0.05）.The HUA prevalence rate was significantly different between people who had different level of blood pressure,cholesterol,hypersensitive C-reactive protein （hs-CRP）,body mass index （BMI）,waisthip ratio （WHR）.The level of uric acid （UA）,total cholesterol （TC） and hs-CRP was significantly different in people with high uric acid when compared with those of normal patients （P〈0.05）.There was positive correlation between UA level and TC,triglyceride （TG） level （r=0.364,P〈0.05;r=0.479,P〈0.05）.Conclusion The HUA prevalence rate increases significantly as people getting older.There is positive correlation between the increase of uric acid level and the major cardiovascular risk factor.People with hypertension,hyperlipidemia,overweight and obese have high risk for HUA,so change life style and dietary habits may prevent or reduce the occurrence of HUA.

关 键 词：老年人 高尿酸血症 心血管疾病 危险因素 

分 类 号：R589.7[医药卫生—内分泌]