多种口服升白药物治疗化疗相关白细胞减少症的实验研究  

Experimental study of chemotherapy related leukocytopenia treated by multiple oral drugs

作　　者：张喜平[1] 张翔[2] 杨红健[1] 邹德宏[1] 何向明[1] 俞星飞[1] 李永峰[1] 

机构地区：[1]浙江省肿瘤医院乳腺外科 [2]上海交通大学医学院附属瑞金医院血液病研究所,上海200025

出　　处：《中国临床药理学与治疗学》2015年第3期246-251,共6页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：浙江省中医药科技计划项目资助(2013ZB026)

摘　　要：目的:通过小鼠实验研究评价5种常用口服升白细胞药物治疗化疗相关白细胞减少症的疗效。方法:采用环磷酰胺腹腔注射法制备小鼠化疗相关白细胞减少症模型,以瑞白为阳性对照药物,分别将5种口服升白细胞药物(芪胶升白胶囊、维血宁、复方皂矾丸、升白安和利可君)灌胃,用全血细胞分析仪测定血细胞计数,解剖小鼠并将其重要脏器称重,计算脏器指数。结果:各组小鼠死亡率无明显差别。按照升白细胞计数的功效,从高到低依次为瑞白、利可君、升白安、维血宁、芪胶升白胶囊、复方皂矾丸,其中芪胶升白胶囊、复方皂矾丸升白细胞作用不明显;除此之外,升白安、利可君还可以提高红细胞计数、血红蛋白浓度及血小板计数。心、脾、肺3个脏器的脏器指数受较多的药物影响,就单种药物而言,升白安对脏器的影响最小,而复方皂矾丸影响的脏器最多。结论:瑞白提升白细胞效果最佳,其次是利可君,升白安对血三系提升均有一定的作用,且对脏器的影响最小。AIM：To evaluate the effects of five routine oral drugs for the treatment of chemotherapy related leukocytopenia in mice experimental study.METHODS：Mice models of chemotherapy related leukocytopenia were established by intraperitoneal injection of cyclophosphamide（CTX）.Mice were treated by Qijiao Shengbai capsules（Q）, Weixuening granule（W）,Compound soap alum pill（S）,berbamine（B）,leucogen（L）,respectively,and Granulocyte Colony-Stimulating Factor（G-CSF）was used as positive control at the same time.Hemocytes were calculated by hematology analyzer and organs were weighted through anatomy for calculating organ indexes.RESULTS：No significant difference in death rate was found in various groups of Mice.Regarding to the effects of promoting peripheric leukocytes,G-CSF,L,B,W,Q and S were in turn of effectiveness from high to low,in which no significant increase in leukocytes was found in Q and S groups.In addition, peripheric erythrocytes, hemoglobin,and platelets were also increased in L and B groups. Organ indexes were calculated, of which heart,spleen,and lung were affected mostly by drugs.As to single drug,B had the least effect on organs and S was the most.CONCLUSION：The best effect of promoting peripheric leukocytes was G-CSF,and L was the second.Furthermore,B possessed the effect of promoting peripheric hemocytes including leukocytes,erythrocytes,platelets,and had the least effect on organ index.

关 键 词：口服升白细胞药物 化疗 白细胞减少 小鼠 

分 类 号：R965.2[医药卫生—药理学]