COPD营养状态模型对呼吸肌蛋白质分解代谢的影响  

Analysis of the influence of COPD model of nutritional status on respiratorymuscle protein catabolism

作　　者：林志勇[1] 梁志科[1] 

机构地区：[1]广州市第一人民医院呼吸内科,广东广州510180

出　　处：《中国医药科学》2015年第5期24-26,共3页China Medicine And Pharmacy

摘　　要：目的探讨COPD营养状态模型对呼吸肌蛋白质分解代谢的影响。方法对我院培育的80例健康Wistar大鼠相关资料进行分析,实验中将这些大鼠随机分为两组,对照组为营养正常大鼠,实验组静脉注射TNF-αMc Ab进行干预,比较两组营养状态模型对呼吸肌蛋白质分解情况。结果实验组大鼠PEF指标为(20.46±2.56)mL/S、FEV0.3指标为(3.69±0.37)mL、FEV0.3/FVC指标为(60.8±4.61)%,均低于对照组大鼠(P<0.05);实验组大鼠血浆葡萄糖为(7.1±0.9)mmol/L、甘油三脂指标为(0.98±0.11)mmol/L,均高于对照组(P<0.05);白蛋白指标为(27.6±1.0)g/L,低于对照组大鼠(P<0.05);实验组大鼠膈肌TNF-α浓度为(31.58±0.98)pg/mL、肋间内肌匀浆中TNF-a浓度为(29.88±1.30)pg/mL,均高于对照组(P<0.05)。结论 TNF-α是引起COPD大鼠发生营养不良以及呼吸肌蛋白质分解代谢率升高的原因之一。Objective To study the nutritional status of COPD model for well the effects of protein catabolism. Methods 80 cases in our hospital to foster healthy Wistar rats related data were analyzed, and the experiment, the rats were randomly divided into two groups, control group for rats, normal nutrition intervention group intravenous TNF alpha McAb, compared two groups of nutrition state model well protein decomposition.Results The experimental group rats PEF index （20.46±2.56）mL/S, FEV0.3 index for （3.69±0.37）mL, FEV0.3 / FVC index for （60.8±4.61）%, the rats were lower than control group （P〈0.05）; Experimental rats plasma glucose （7.1±0.9）mmol/L tendency, triglycerides index for l （0.98±0.11）mmol/L tendency for l, were higher than control group （P〈0.05）; Albumin index for （27.6±1.0）g/L, lower than the control group rats （P〈0.05）; TNF- a concentration in the experimental group rats diaphragm for （31.58±0.98）pg/mL, rib inside muscle homogenate of TNF - a concentration of （29.88±1.30）pg/mL, were higher than control group （P〈0.05）.Conclusion TNF alpha is cause malnutrition and COPD rats well one of the reasons for protein catabolic rate increases.

关 键 词：COPD营养状态模型 呼吸肌蛋白质分解代谢 影响 

分 类 号：R563.9[医药卫生—呼吸系统]