核医学示踪技术的应用研究  

Study on the Application of Nuclear Medicine Tracer Technique

作　　者：王荣福[1] 王飞[1] 李颖[1] 

机构地区：[1]北京大学第一医院,北京100034

出　　处：《肿瘤学杂志》2015年第4期261-263,共3页Journal of Chinese Oncology

基　　金：国家自然科学基金(81071183);国家重大科学仪器设备开发专项(2011YQ03011409);十二五国家支撑项目基金(2014BAA03B03)

摘　　要：放射性核素示踪技术是研究示踪剂在生物体系或外界环境中分布及运动规律的一门科学,主要基于放射性示踪剂与被测研究物质具有相同的化学性质和生物学行为,即同一性和可测性。放射性核素示踪剂在体内的生物学行为主要取决于被标记化合物,而其标记在化学分子上的放射性核素在整体示踪研究体系中主要起示踪作用。因此,核医学核素示踪体外分析、功能测定、显像及靶向治疗是无创、安全的,且可提供精确的定性、定量和定位信息。Radionuclide tracer technique is the science to study the distribution and mechanism of tracer in biological systems as well as the external environment. Radionuclide tracer technique is mainly based on the same chemical property（identity） and biological behaviors（measurability）between the tracer and the researched materials. The biological behavior of radionuclide tracer in vivo depends mainly on the tracer,and the radionuclide than labeled with tracer could be detected in the research system. Therefore,in vitro radioassay,functional measurement,imaging and targeted therapy based on tracer technique of nuclear medicine are a noninvasive,safe and providing precise location as well as qualitative and quantitative information methods.

关 键 词：核医学 放射性核素 示踪技术 生物学行为 靶向 

分 类 号：R817[医药卫生—影像医学与核医学]