舒血宁注射液对急性胰腺炎患者氧化应激状态的影响  

The effects of Shuxuening parenteral solution on oxidate stress in patients with acute pancreatitis

作　　者：谢中华[1] 汪铁军[1] 郑元秀[1] 黄芳芳[1] 王建儿 王珠美[1] 

机构地区：[1]杭州市余杭区第二人民医院内二科,浙江杭州311121

出　　处：《中国中西医结合消化杂志》2015年第4期238-241,共4页Chinese Journal of Integrated Traditional and Western Medicine on Digestion

摘　　要：[目的]观察舒血宁注射液对急性胰腺炎(AP)患者氧化应激水平的影响。[方法]79例AP患者随机分成治疗组(41例)和对照组(38例),对照组给予AP常规治疗,治疗组在此基础上予舒血宁注射液20ml稀释后静脉注射,1次/d,共10d,观察治疗前后疗效及氧化应激水平的变化。[结果]治疗前,治疗组及对照组血清IL-6、TNF-α、SOD、MDA水平及CTSI、APACHEⅡ评分比较,差异无统计学意义。治疗后,治疗组血清IL-6、TNF-α、MDA水平及CTSI、APACHEⅡ评分与对照组比较明显降低(P<0.01,P<0.05),而血清SOD则显著升高(P<0.01)。相关性分析表明:血清SOD水平与血清IL-6、TNF-α水平及CTSI、APACHEⅡ评分均呈明显负相关(r分别为-0.720、-0.538、-0.422、-0.661,P<0.01);血清MDA水平与血清IL-6、TNF-α水平及CTSI、APACHEⅡ评分均呈明显正相关(r分别为0.505、0.796、0.473、0.809,P<0.01)。[结论]舒血宁注射液联合常规疗法临床疗效明显优于单用常规疗法,其机制可能与其抗氧化,清除氧自由基的作用有关。[Objective]To investigate the effects of shuxuening parenteral solution on oxidate stress in patients with acute pancreatitis.[Methods]Seventy-nine patients with acute pancreatitis were divided into 2groups at random,38 in the control group and 41 in the experimental group.Patients in the control group received acute pancreatitis routine treatment.Patients in the experiment group were given shuxuening parenteral solution in addition to routine treatment.Ten days were one treatment course.The efficacy and oxidative stress state were analyzed.[Results]There were no significant difference at the levels of serum IL-6、TNF-α、SOD、MDA and the scores of CTSI、APACHEⅡbetween control group and experimental group at pre-treatment.After treatment,the levels of serum IL-6、TNF-α、MDA and the scores of CTSI、APACHEⅡof experiment group were decreased significantly than that of control group（P〈0.01,P〈0.05）,while the levels of serum SOD of experiment group were increased significantly than that of control group（P〈0.01）.There was a significant negative correlation between serum SOD and the levels of serum IL-6、TNF-α、the scores of CTSI、APACHEⅡ（r=-0.720、-0.538、-0.422、-0.661,P〈0.01）;The significant positive correlation was also seen between serum MDA and the levels of serum IL-6、TNF-α、the scores of CTSI、APACHEⅡ（r=0.505、0.796、0.473、0.809,P〈0.01）.[Conclusion]The clinical outcome of treating acute pancreatitis with shuxuening parenteral solution combined with routine treatment therapy was remarkably better than that of routine treatment alone.Antioxidan and scavenging oxygen free radicals may be a possible mechanism for shuxuening parenteral solution to treat acute pancreatitis.

关 键 词：舒血宁注射液 急性胰腺炎 氧化应激 

分 类 号：R657.51[医药卫生—外科学]