阿托伐他汀对62例早期糖尿病肾病的疗效观察  

Curative effects observation of atorvastatin for treatment of 62 cases of early diabetic nephropathy

作　　者：陈庆[1] 欧伟宁[1] 庞丹丹[1] 

机构地区：[1]玉林市第二人民医院肾内科,广西玉林537000

出　　处：《四川生理科学杂志》2015年第1期19-21,共3页Sichuan Journal of Physiological Sciences

摘　　要：目的:探讨阿托伐他汀早期干预糖尿病肾病的临床效果。方法:将62例符合2型糖尿病并发早期肾病患者随机分为治疗组和对照组,每组31例。在常规治疗的基础上,治疗组给予阿托伐他汀40 mg及拜阿司匹林0.1 g;对照组给予阿托伐他汀20 mg及拜阿司匹林0.1 g,均为Qd,口服,疗程4周,并进行疗效评价。结果:治疗前后两组患者的U-m Alb、UAER、Scr、TG等指标均明显下降(P<0.05),且治疗组(口服阿托伐他汀40 mg)各项指标改善优于对照组(口服阿托伐他汀20 mg)(P<0.05)。结论:中等剂量的阿托伐他汀辅助治疗早期糖尿病肾病,可有效改善肾功能,不良反应较少,有着积极的临床价值。Objective： To investigate clinical effects of atorvastatin on early diabetic nephropathy. Methods： A total of 62 cases with type 2 diabetes mellitus with early nephropathy had been randomly divided equally into two groups. All patients received routine therapy, the patients in treatment group daily received atorvastatin 40 mg plus aspirin 0. 1 g, and the patients in control group daily received atorvastatin 20 mg plus aspirin 0. 1 g. All patients were observed for 4 months to compare the changes. Results： The level of U-mAlb, UAER, Scr and TG were significantly cut down in two groups after 4 months（P〈0. 05）, and all the indicators of the treat- ment group were better than the control group. Conclusions： The use of median dose of atorvastatin can effectively improve renal function and reduce adverse reaction in patients with type 2 diabetes mellitus with early nephropathy.

关 键 词：早期糖尿病肾病 阿托伐他汀 疗效观察 

分 类 号：R587.2[医药卫生—内分泌]