脑钠肽与D-二聚体在间质性肺疾病急性加重期中的预测价值  

Predictive value of brain natriuretic peptide and D-dimer in acute exacerbation of interstitial lung disease

作　　者：王高明[1] 任重[2] 

机构地区：[1]松滋市人民医院呼吸内科,湖北松滋434200 [2]松滋市人民医院心内科,湖北松滋434200

出　　处：《临床肺科杂志》2015年第5期857-859,共3页Journal of Clinical Pulmonary Medicine

摘　　要：目的本文主要探讨脑钠肽与D-二聚体在间质性肺疾病急性加重期中的预测价值。方法选取2011.01至2013.12入住我院的间质性肺疾病急性加重期患者38例,入院时常规检测脑钠肽与D-二聚体。根据预后分为生存组(n=20例)及死亡组(n=18例),将两组入院时所检测脑钠肽与D-二聚体值进行比较分析。结果间质性肺疾病急性加重期死亡组脑钠肽(735.3±138.4)pg/ml与D-二聚体(4444.9±1600.4)ng/ml值较生存组脑钠肽(31.5±9.0)pg/ml与D-二聚体(422.9±215.7)ng/ml显著升高,两者比较,P<0.05,有统计学意义。结论脑钠肽与D-二聚体检测作为间质性肺疾病急性加重期判断预后的指标。Objective To explore the predictive value of brain natriuretic peptide and D-dimer in acute exacerbation period of interstitial lung disease. Methods 38 patients with acute exacerbation period of interstitial lung disease were chosen as the study group from January 2011 to December 2013 in our hospital,and their brain natriuretic peptide and D-dimmer were detected. According to the prognosis of these patients,they were divided into the survival group（ n = 20 cases） and the death group（ n = 18）. The value of brain natriuretic peptide and D-dimer of the two groups were analyzed. Results The level of brain natriuretic peptide was（ 735. 3 ± 138. 4） pg / ml and D-dimer was（ 4444. 9 ± 1600. 4） ng / ml in the death group,which were significantly higher than those in the survival group（（ 31. 5 ± 9. 0） pg / ml and（ 422. 9 ± 215. 7） ng / ml）（ P〈0.05）. Conclusion The detection of brain natriuretic peptide and D-dimer can be as predictive index to verdict the prognosis of acute exacerbation period of interstitial lung disease.

关 键 词：脑钠肽 D-二聚体 间质性肺疾病 预测价值 

分 类 号：R563.9[医药卫生—呼吸系统]