脑钠肽及降钙素原在老年重症肺炎患者早期评估中的作用  

Application of procalcitonin and brain natriuretic peptide for early evaluation of elderly patients with severe pulmonary infectious diseases

作　　者：孙慧[1] 李秀芝[2] 郭霞[2] 王红阳[2] 李佳宁[3] 

机构地区：[1]唐山市第四医院,河北唐山063000 [2]河北联合大学附属医院呼吸科,河北唐山063000 [3]唐山市人民医院,河北唐山063000

出　　处：《临床肺科杂志》2015年第5期877-880,共4页Journal of Clinical Pulmonary Medicine

摘　　要：目的分析降钙素原及脑钠肽水平在老年重症肺炎患者早期评估中的作用。方法 65例老年重症肺炎患者为观察组,以同期收治48例一般肺部感染老年患者和45例非感染性疾病患者为对照组1和对照组2,分别在治疗前和治疗后1 d、3 d、5 d检测血浆脑钠肽(BNP)和降钙素原(PCT);结合7 d内患者的病情情况分析BNP及PCT在老年重症肺炎患者早期评估中的作用。结果观察组BNP及PCT水平显著高于与对照1和对照组2;病情好转组治疗3 d、5 d时BNP及PCT水平低于恶化组;PCT预测患者预后的ROC曲线下面积为0.912(灵敏度为0.793、特异度为0.914;BNP预测预后的ROC曲线下面积为0.674、灵敏度为0.745、特异度为0.509。结论 PCT动态变化优于BNP,可反映老年重症肺炎患者早期病情转归情况。Objective To analyze the role of procalcitonin（ PCT） and brain natriuretic peptide（ BNP） for evaluating the prognosis of elderly patients with severe pulmonary infectious diseases. Methods 65 severe pulmonary infectious diseases patients were selected as the observation group,and 48 elderly patients with pulmonary infectious diseases and 45 patients with non-infectious diseases were taken as the control group 1 and the control group2.The levels of BNP and PCT were measured before and 1d,3d and 5d after the treatment. Results The levels of BNP and PCT were significantly higher in the observation group than in the control group 1 and 2. The levels of BNP and PCT were lower in the observation group than in the worsening group. Area under the ROC curve for PCT was 0. 912,the sensitivity was 0. 793,and the specificity was 0. 914. Area under the ROC curve for BNP was 0. 674,the sensitivity was 0. 745,and the specificity was 0. 509. Conclusion The dynamic changes of PCT level are superior to the BNP level,which can reflect the prognosis for the early evaluation of elderly patients with severe pulmonary infectious diseases.

关 键 词：脑钠肽 降钙素原 重症肺炎 老年 

分 类 号：R563.1[医药卫生—呼吸系统]