1959~1961年青岛地区出生人群高血压发病情况及其相关因素研究  

Study on Hypertension and Related Factors Among the People Born during 1959-1961in Qingdao City

作　　者：王玮[1] 孙健平[1,2] 崔静[1,2] 庄桂丽 宁峰[2] 刘丽[2] 逄增昌[1,2] 

机构地区：[1]青岛大学医学院公共卫生系,山东青岛266021 [2]青岛市疾病预防控制中心,山东青岛266033

出　　处：《预防医学论坛》2015年第3期161-164,168,共5页Preventive Medicine Tribune

基　　金：世界糖尿病基金会项目(WDF07-308)

摘　　要：目的探讨高血压的相关危险因素及生命早期食物短缺和营养不良对成年后高血压患病危险的影响。方法采用分层随机抽样的方法选取青岛市35~74岁居民为调查对象,将1962~1970年、1959~1961年大饥荒期间和1953~1958年出生人群分别定义为非暴露组、胚胎期暴露组和儿童期暴露组。采用SPSS 17.0统计软件,分析高血压相关危险因素并比较不同组患高血压危险性。结果胚胎期暴露组及儿童期暴露组高血压、糖尿病、高血脂等患病率均高于非暴露组（P〈0.05）。是否经历大饥荒、年龄、地域、BMI、高血脂、糖尿病等13个因素与高血压的发生相关（P〈0.05）。单因素Logistic分析显示,相对于非暴露组,胚胎期暴露组和儿童期暴露组的相对危险度（OR）（95%CI）分别为2.21（1.80~2.70）、2.66（2.07~3.01）;多因素Logistic分析显示,仅调整高血压基本影响因素,2组的OR（95%CI）为1.63（1.25~2.13）、1.54（1.09~2.19）;在上述基础上再调整疾病因素,2组的OR（95%CI）为1.56（1.19~2.05）、1.44（1.01~2.06）;最后调整所有混杂因素,2组的OR（95%CI）为1.60（1.21~2.11）、1.53（1.06~2.21）。结论高血压是多因素综合作用所致,生命早期经历食物短缺和营养不良等灾害可能增加成年后患高血压的危险性。Objective To explore the risk factors of hypertension and effects to hypertension after adult because of food shortages and malnutrition in early life. Methods Stratified random cluster sampling method was conducted to select residents aged 35-74 in Qingdao city.People born during 1962-1970,1959-1961 during the great famine and 1953-1958 were defined as the non-exposed group,embryonic exposed group,and childhood exposed group.Analysis was made on the risk factors of hypertension and comparison on the hazard of hypertension in different groups by SPSS 17.0. ResultsThe hypertension,diabetes and hyperlipidemia prevalence of embryonic exposed group and childhood exposed group was all higher than that of non-exposed group（P〈0.05）.13 factors such as whether through famine,age,geographic,BMI,hyperlipidemia,diabetes and so on were associated with hypertension（P〈0.05）.Binary logistic regression reflected that,compared with non-exposed group,the OR（95%CI）of embryonic and childhood exposed group was 2.21（1.80-2.70）and2.66（2.07-3.01）;Multinomial logistic regression reflected that,only adjusted the basic influencing factors of hypertension,the OR（95%CI）of two groups were 1.63（1.25-2.13）and 1.54（1.09-2.19）;adjusted for diseases on the basis of above factors,the OR（95%CI）of two groups was 1.56（1.19-2.05）and 1.44（1.01-2.06）;after adjusted all confounding factors,the OR（95%CI）of two groups was 1.60（1.21-2.11）and 1.53（1.06-2.21）. Conclusion Hypertension is caused by multiple factors,early life has experienced food shortages and malnutrition or other disasters may increase the risk of hypertension in adulthood.

关 键 词：高血压 营养不良 患病率 危险因素 

分 类 号：R544.1[医药卫生—心血管疾病]