可溶性黏附分子水平与系统性红斑狼疮中医辨证分型的关系  

Relationship between soluble adhesion molecule level and SLE syndrome differentiation of TCM

作　　者：甄珠 刘克芹[2] 

机构地区：[1]赤峰市第二医院检验科,内蒙古赤峰024000 [2]河北北方学院附属第一医院,河北张家口075000

出　　处：《长春中医药大学学报》2015年第2期345-347,共3页Journal of Changchun University of Chinese Medicine

基　　金：河北省卫生厅资助项目(05094)

摘　　要：目的检测系统性红斑狼疮(SLE)患者血清可溶性黏附分子水平,并分析其与SLE不同中医辨证分型的相关性及诊断价值。方法选取SLE患者46例,辨证分型为热毒炽盛型19例,脾肾阳虚型14例,肝肾阴虚型13例,取晨起空腹静脉血,采用ELISA法检测其血清可溶性细胞间黏附分子-1(SICAM-1)及血管内皮细胞黏附分子-1(SVCAM-1)水平变化,并设同期来院体检正常者40例为对照组,进行对比分析。结果各证型血清SICAM-1、SVCAM-1水平均显著高于对照组(P<0.05);热毒炽盛型血清SICAM-1、SVCAM-1水平显著高于脾肾阳虚型及肝肾阴虚型(P<0.05);脾肾阳虚型2项指标显著高于肝肾阴虚型(P<0.05);SLE狼疮活动积分及ESR以热毒炽盛型最高,依次为脾肾阳虚型及肝肾阴虚型(P<0.05);热毒炽盛型及脾肾阳虚型补体C3滴度显著低于肝肾阴虚型(P<0.05);SICAM-1与SVCAM-1两种分子间呈正相关性(P<0.01);血清SICAM-1、SVCAM-1水平与狼疮积分、ERS呈正相关(P<0.01);与补体C3呈负相关(P<0.01)。结论血清SICAM-1、SVCAM-1水平测定可作为判定SLE活动的重要指标,检测SLE患者血清可溶性黏附分子水平可作为中医辨证论治辅助指标。Objective To detect the serum soluble adhesion molecule level in the SLE patients and to analyze its relationship with different SLE syndrome differentiation of TCM and its diagnostic value. Methods A total of 46 SLE patients were enrolled in our study,among which 19 cases belonged to the type of heat-toxin flaming,14 had spleen-kidney-yang deficiency,and 13 had liver-kidney-yin deficiency according to the syndrome differentiation of TCM. The morning fasting venous blood of all subjects was obtained to detect the changes of levels of SICAM-1 and SVCAM-1 by ELISA. A total of 40 healthy individuals who came for physical examination at the same stage were served as the control and comparative analysis was conducted. Results The levels of serum SICAM-1 and SVCAM-1 in all types of the SLE patients were significantly higher than those in the control group（ P〈 0. 05）; the levels of serum SICAM-1 and SVCAM-1 in the heat-toxin flaming type were significantly higher than those in the patients with spleen-kidney-yang deficiency and liver-kidney-yin deficiency（ P〈 0. 05）; the levels of these two indicators in the spleen-kidney-yang deficiency patients were significantly higher than those in the liver-kidney-yin deficiency patients（ P〈 0. 05）; the heattoxin flaming patients had the highest SLE disease activity index（ SLEDAI） and ESR,secondly,was the spleen-kidney-yang deficiency patients,and the liver-kidney-yin deficiency patients had the least（ P〈 0. 05）; the C3 titers in the heat-toxin flaming and spleen-kidney-yang deficiency patients were significantly lower than those in the liver-kidney-yin deficiency patients（ P〈 0. 05）; while the comparison of the C3 titers between the heat-toxin flaming and spleen-kidney-yang deficiency patients was not statistically different（ P〈 0. 05）; there was a positive correlation of SICAM-1 and SVCAM-1 in the SLE patients（ P〈 0. 01）; The serum SICAM-1 and SVCAM-1 levels were positively correlated with the SLEDAI（ P〈 0. 01） and ESR（ P〈 0

关 键 词：系统性红斑狼疮 辨证分型 可溶性黏附分子 

分 类 号：R275.9[医药卫生—中西医结合]