龟芪散对小鼠免疫调节作用的拆方分析  

Effect of Gui Qi San and its separated prescription on immunoregulative effect in mice

作　　者：朱晓新[1] 王盟 吴敦序 章育正[2] 宫斌[2] 方肇勤[2] 徐品初[2] 王韧[2] 奚蓓莉[2] 廖菡[2] 

机构地区：[1]中国中医研究院西苑医院基础室,北京100091 [2]上海中医药大学

出　　处：《中国临床药理学与治疗学杂志》1998年第2期94-98,共5页

基　　金：上海市教委资助课题

摘　　要：目的观察龟芪散及其拆方对小鼠免疫功能的调节作用。方法用环磷酰胺损伤小鼠的免疫功能 ,分析龟芪散及其拆方对淋巴细胞的影响。结果该方可明显对抗环磷酰胺引起的小鼠脾脏的退化或提高其内在质量 ;促进免疫受损小鼠T、B淋巴细胞增殖 ;促进NK活性 ;通过增加CD4 + 细胞数量而提高CD4 + /CD8 + 细胞比率 ;降低免疫受损小鼠脾细胞内cAMP水平。全方效果好于拆方 ,亦好于云芝多糖(PSP)。但对正常小鼠的免疫功能无明显影响。结论龟芪散具有免疫调节效应。Aim The immunoregulative effect of Gui Qi San and its separated prescription on immune functions of mice was to be studied. Methods The effect of Gui Qi San and its separated prescription on lymphocytes was observed after the immune function of mice was damaged by cyclophosphamide. Results They could evidently counteract mice spleen degeneration caused by cyclophosphamide or improve their life quality, promote immunosuppressied mice T.B lymphocytes proliferation, activate NK cells, increase CD 4+/CD 8+ cells ratro by increasing CD4+ cell, and lowere cAMP level in spleen cell. The composite prescription had better effect than its separated prescription and PSP. It had no effect on immune function of normal mice. Conclusion Gui Qi San and its separated prescription had immunoregulative effect on immunosuppressied mice.

关 键 词：龟芪散 小鼠 免疫调节作用 拆方分析 

分 类 号：R285.5[医药卫生—中药学]