GnRHa治疗对ICPP患儿子宫和卵巢超声变化的影响  

Effect of GnRHa on uterine and ovarian ultrasonic changes of ICPP children

作　　者：李明珠[1] 董国庆[1] 蒋绍艳[1] 张忠菊[1] 黄秒[1] 陈昱[1] 李坚旭[1] 

机构地区：[1]南方医科大学附属深圳妇幼保健院儿科,广东深圳518028

出　　处：《中国妇幼保健》2015年第12期1933-1935,共3页Maternal and Child Health Care of China

基　　金：深圳市知识创新计划项目〔JYC20130402090948811〕

摘　　要：目的：观察促性腺激素释放激素类似物（Gn RHa）对特发性中枢性性早熟（ICPP）患儿子宫和卵巢超声变化的影响,探讨子宫和卵巢超声检查对Gn RHa治疗ICPP疗效评估的价值。方法：选取2013年1-12月在该院就诊的ICPP患儿20例,分别在Gn RHa治疗前和治疗后6个月进行子宫、卵巢超声检查和Gn RH激发试验,采用SPSS 13.0软件分析比较治疗前后子宫、卵巢的超声改变和促性腺激素（黄体生成素、促卵泡素）峰值变化。结果：治疗后ICPP患儿的子宫容积、子宫长度、卵巢容积、卵巢面积、卵泡个数和卵泡最大直径均较治疗前明显缩小或减少,差异有统计学意义（P均〈0.05）,与黄体生成素、促卵泡素峰值变化一致。结论 ：子宫、卵巢的超声改变可间接反映ICPP患儿的垂体-性腺轴功能状况,是ICPP患者诊断和疗效观察的一种简单、可靠、实用的方法。Objective： To observe the effect of gonadotropin-releasing hormone analogue（ Gn RHa） on uterine and ovarian ultrasonic changes of children with idiopathic central precocious puberty（ ICPP）,explore the value of uterine and ovarian ultrasonography in evaluation of curative effect of Gn RHa. Methods： Twenty ICPP children treated in the hospital from January to December in 2013 were selected,uterine and ovarian ultrasonography and Gn RH stimulating test were conducted before treatment and at six months after treatment;SPSS 13. 0 software was used to analyze and compare uterine and ovarian ultrasonic changes and peak values of gonadotropins（ luteinizing hormone and follicle- stimulating hormone） before and after treatment. Results： After treatment,uterine volume,uterine length,ovarian volume,ovarian area,the number of follicles,and the maximum diameter of follicles among ICPP children decreased,there were statistically significant differences（ P〈0. 05）,the changes were coincidence with changes of peak values of luteinizing hormone and follicle-stimulating hormone. Conclusion： Uterine and ovarian ultrasonic changes can indirectly reflect pituitary-gonad axis function of ICPP children,which is a simple,reliable,and practical method for diagnosing ICPP and observing curative effect.

关 键 词：促性腺激素释放激素类似物 特发性中枢性性早熟 治疗 子宫 卵巢 超声 

分 类 号：R179[医药卫生—妇幼卫生保健]