3种硝基咪唑类药物治疗滴虫性阴道炎的有效性及不良反应研究  

Study on the effectiveness and adverse reactions of three nitroimidazoles in treatment of trichomonas vaginitis

作　　者：祖恩慧 张岚[1] 于龙飞 

机构地区：[1]安徽省芜湖市第二人民医院妇产科,241000 [2]吉林省春光康复医院妇产科

出　　处：《中国妇幼保健》2015年第12期1936-1938,共3页Maternal and Child Health Care of China

摘　　要：目的：探讨奥硝唑（ONZ）、甲硝唑（MNZ）和替硝唑（TNZ）治疗滴虫性阴道炎（TMV）的有效性和安全性,为TMV的治疗提供理论依据。方法：选取2010年10月-2013年10月该院收治的195例TMV患者,分为ONZ组、TNZ组和MNZ组,每组各65例。治疗方案按ONZ、MNZ和TNZ方案执行,治疗后按标准进行疗效和不良反应评定,并对数据进行统计学分析。结果：ONZ组痊愈54例（83.07%）,总有效率为98.56%,与其他两组比较,差异有统计学意义（χ^2=9.085、9.152,P均〈0.05）。ONZ组出现不良反应7例（10.77%）,与其他两组比较,差异有统计学意义（χ^2=8.645、8.686,P均〈0.05）。结论：ONZ方案在疗效和不良反应方面优于MNZ和TNZ组,故临床治疗TMV应优先选择ONZ方案。Objective： To explore the effectiveness and safeties of ornidazole（ ONZ）,metronidazole（ MNZ）,and tinidazole（ TNZ） in treatment of trichomonas vaginitis,provide a theoretical basis for treatment of trichomonas vaginitis. Methods： A total of 195 patients with trichomonas vaginitis treated in the hospital from October 2010 to October 2013 were selected and divided into ONZ group,TNZ group,and MNZ group,65 patients in each group. After treatment,the curative effect and adverse reactions were evaluated according to the standard,the data was analyzed statistically. Results： In ONZ group,54 patients（ 83. 07%） were cured,the total effective rate was98. 56%,compared with the other two groups,there were statistically significant differences（ χ^2= 9. 085,P0. 05; χ^2= 9. 152,P0. 05）.Adverse reactions occurred in seven patients（ 10. 77%） in ONZ group,compared with the other two groups,there were statistically significant differences（ χ^2= 8. 645,P0. 05; χ^2= 8. 686,P0. 05）. Conclusion： ONZ is superior to MNZ and TNZ in aspects of curative effect and adverse reactions,so ONZ should be preferred in treatment of trichomonas vaginitis.

关 键 词：奥硝唑 甲硝唑 替硝唑 滴虫性阴道炎 

分 类 号：R711.31[医药卫生—妇产科学]