唐山地区汉族人群血管紧张素转换酶基因多态性与冠心病的相关性研究  

Correlation between gene polymorphism of angiotensin-converting enzyme and coronary heart disease in population of Han nationality in Tangshan region

作　　者：赵佩[1] 赵红[1] 曹新营[1] 张文静[1] 葛庆锋[1] 李海涛[1] 

机构地区：[1]河北联合大学附属医院心内科,唐山063000

出　　处：《中国循证心血管医学杂志》2015年第2期221-224,共4页Chinese Journal of Evidence-Based Cardiovascular Medicine

摘　　要：目的探讨血管紧张素转换酶(ACE)基因插入/缺失(insertion/deletion,I/D)多态性与冠状动脉粥样硬化性心脏病(冠心病)及冠状动脉(冠脉)病变支数间的关系。方法选取住院患者332例,其籍贯均为河北唐山地区,行冠脉造影术检查判定其是否患有冠心病及其冠脉病变支数。根据造影结果分为冠心病组(至少有一支冠脉主支血管狭窄≥50%)233例(稳定型心绞痛亚组150例、急性冠脉综合征组亚组83例)和对照组99例(任一冠脉主支血管狭窄<50%)。应用聚合酶链式反应技术检测患者ACE基因I/D多态性,包括II型(插入型纯合子)、ID型(插入与缺失型杂合子)、DD型(缺失型纯合子)三组,并分析不同组别间I/D多态性差异。结果冠心病组及急性冠脉综合征亚组ACE基因DD型和D等位基因频率显著高于对照组(P<0.05)。稳定型心绞痛组与对照组比较DD基因型和D等位基因频率间并无显著差异(P>0.05)。不同冠脉病变支数在ACE基因型间差异无统计学意义(P>0.05)。结论唐山地区汉族人群ACE基因I/D多态性中DD型和D等位基因发生率冠心病及急性冠脉综合征患者中增高,但与冠脉病变支数无关。Objective To discuss the relationship between gene insertion/deletion （I/D） polymorphism of angiotensin-converting enzyme （ACE） and coronary heart disease （CHD） or number of diseased coronary vessels. Methods The in-hospital patients （n=332, all from Tangshan region of Hebei Province） were chosen and given coronary angiography （CAG） for adjusting whether or not they suffered from CHD and number of diseased coronary vessels. According to the outcomes of CAG, the patients were divided into CHD group [at least 1 coronary major branch being stenosis≥50%,n=233, among them 150 were in stable angina pectoris （SAP） subgroup and 83 in acute coronary syndrome （ACS） subgroup] and control group （n=99, anyone coronary major branch being stenosis〈50%）. I/D polymorphism of ACE was detected by using polymerase chain reaction （PCR）, including type II （type of insertion homozygous）, type ID （type of insertion and deletion heterozygous） and type DD （type of deletion homozygous）, and the difference in I/D polymorphism were compared among all groups.Results The frequency of type DD and D allele was significantly higher in CHD group and ACS subgroup than that in control group （P〈0.05）, and that had no significant difference between SAP subgroup and control group （P〉0.05）. The difference in number of diseased coronary vessels had no statistical significance among different ACE gene types （P〉0.05）.Conclusion In population of Han nationality in Tangshan region, type DD and D allele of ACE I/D polymorphism increase in patients with CHD and ACS, which, however, is not correlated to number of diseased coronary vessels.

关 键 词：冠心病 血管紧张素转换酶 基因多态性 唐山地区 

分 类 号：R541.4[医药卫生—心血管疾病]