抗体修饰纳米载体表面构建主动靶向制剂常用偶联方法  

Surface Modifi cation Strategies of Nanocarriers with Antibody as Targeting Agents

作　　者：柳帅[1] 刘洁[1] 杨亚妮[1] 何军[1] 

机构地区：[1]中国医药工业研究总院药物制剂国家工程研究中心,上海200437

出　　处：《中国医药工业杂志》2015年第4期404-411,共8页Chinese Journal of Pharmaceuticals

摘　　要：近年来出现了多种抗体修饰的主动靶向纳米载体,克服了载体本身的局限性。本文综述了目前常用的抗体修饰纳米载体表面的方法,对其进行了概括和分类,主要包括吸附法为主的非共价偶联法,以及采用偶联剂作催化剂进行反应的共价偶联法,并比较了各自的优缺点和适用条件,此外还介绍了常见的几种偶联抗体及相应受体,最后展望了主动靶向制剂的应用前景。In recent years, there have been many active targeted nanocarriers surface modifi ed by antibodies occurring to overcome the limitations of nanocarriers. Most commonly used antibody surface modification methods are reviewed in this paper. It mainly includes non-covalent coupling methods based on adsorption effect and covalent coupling methods with or without coupling agent. Then this article highlights the differences between these methods, including their advantages and disadvantages. Next, surface modifi cation methods of nanocarriers and several common antibodies are introduced. Finally, present limitations and future challenges are discussed.

关 键 词：纳米载体 抗体 表面修饰 靶向制剂 综述 

分 类 号：R944.9[医药卫生—药剂学]