中国人群维生素B_(12)、叶酸与巨幼细胞性贫血相关性Meta分析  

The Correlation Between Vitamin B12,Folic Acid and Megaloblastic Anemia in the Chinese Population: a Meta-analysis

作　　者：宰宇 高露[1] 谭淼[1] 翦耀文 刘雨阳[1] 让蔚清[1] 

机构地区：[1]南华大学公共卫生学院,湖南衡阳421001

出　　处：《中南医学科学杂志》2015年第2期125-131,149,共8页Medical Science Journal of Central South China

基　　金：国家863项目(2012AA063501);公共卫生与预防医学湖南省十二五重点学科;疾病控制评价中心南华大学校级重点实验室;湖南省卫生厅科研项目(B2010-043);湖南省研究生科研创新项目(2014SCX10);南华大学哲学社会科学基金(2011xwt05;2011xwt06)资助

摘　　要：目的采用Meta分析方法综合定量评价中国人群维生素B12、叶酸与巨幼细胞性贫血相关性。方法检索国内外相关中英文数据库文献,并按照事先定义的纳入和排除标准,剔除不符合要求的文献,对纳入文献采用Meta分析方法进行综合定量分析,对17篇研究进行综合分析,累计病例625例,对照1 296例;用Stata 12.0进行分析,Q检验和I2检验反映异质性的大小,发表偏倚用漏斗图法、Begg秩相关和Egger线性回归法识别。结果巨幼细胞性贫血组的维生素B12含量低于对照组,差异有统计学意义(Z=5.86,P=0.00);巨幼细胞性贫血组的叶酸含量低于对照组,差异有统计学意义(Z=5.58,P=0.00)。结论巨幼细胞性贫血与血清维生素B12、叶酸含量水平有直接的关系,单一缺乏或者两者都缺乏均会引起巨幼细胞性贫血。Objective To quantify the correlation between vitamin B12,folic acid and megaloblastic anemia in Chinese population. Methods Meta-analysis was performed by using Stata12. 0. Seventeen electronic databases of case-control studies from January 1959 to July 2014 were systematically searched on the basis of the published studies evaluating the correlation between vitamin B12,folic acid and megaloblastic anemia. A total of 625 cases and 1296 control cases were enrolled in the study. Cochrane＇s Q and I2 statistics were used to evaluate heterogeneity among studies and standardized mean difference（ SMD） were calculated using random-effects models. And publication bias was also calculated by funnel plot,Egger linear regression test and Begg rank correlation test. Results There exists discrepancy between megaloblastic anemia group and control group at the level of serum vitamin B12（ Z = 5. 86,P = 0. 000）. There exists discrepancy between megaloblastic anemia group and control group at the level of serum folic acid（ Z = 5. 58,P = 0. 000）. Conclusion The levels of vitamin serum B12 and folic acid are straightly related to megaloblastic anemia. Either or both of vitamin B12 and folic acid deficiencies induce megaloblastic anemia.

关 键 词：巨幼细胞性贫血 维生素B12 叶酸 META分析 

分 类 号：R556[医药卫生—血液循环系统疾病]