银杏达莫注射液致不良反应192例分析  

Analysis of 192 Cases of Adverse Drug Reactions Induced by Ginkgo Leaf Extract and Dipyridamole Injection

作　　者：林南星[1] 王景红[1] 梅娜[1] 朱兰[2] 

机构地区：[1]中国中医科学院望京医院药学部,北京100102 [2]北京市药品不良反应监测中心,北京100054

出　　处：《中国药房》2015年第12期1607-1609,共3页China Pharmacy

基　　金：中国中医科学院望京医院科研课题(No.WJY-Y2014-YY051)

摘　　要：目的:探讨银杏达莫注射液致不良反应(ADR)的一般规律和特点,为临床合理用药提供参考。方法:检索2010—2013年北京市药品不良反应监测中心收集的各监测单位提交的药品不良反应/事件报告中涉及的银杏达莫注射液致ADR病例,并就收集到的192例ADR相关信息进行统计和分析。结果:银杏达莫注射液致ADR女性及中老年患者发生率较高,主要表现为神经系统异常、消化系统及皮肤反应;ADR多发生于用药后2 h内(83.44%),以速发型为主,无死亡病例,所有患者经停药或对症治疗后均恢复正常。结论:银杏达莫注射液致ADR与用药剂量、患者性别及年龄有关,临床应加强用药监测,减少ADR的发生,确保用药安全。OBJECTIVE：To investigate the regulation and characteristics of adverse drug reactions（ADR）of the Ginkgo leaf extract and dipyridamole injection（GLEDI）and provide reference for the rational drug use in clinic. METHODS：GLEDI ADR cases in the adverse drug reaction/event reporting presented by monitoring organizations were collected from Beijing Center for ADR Monitoring（BCDR）from 2010 to 2013 and totally 192 ADR cases were statistically analyzed. RESULTS：The incidence of ADR induced by GLEDI was higher in female middle and eldery patients;it was mainly neurologic system abnormalities,digestive system and skin reactions. ADR often appeared within 2 h（83.44%）,mainly immediate type. There was no death case and all patients were recovered after drug withdrawal or symptomatic treatment. CONCLUSIONS：The ADR induced by the GLEDI is associated with doses,gender and age. Clinic should strengthen medication monitoring to reduce the ADR incidence and ensure drug safety.

关 键 词：银杏达莫注射液 不良反应 监测 分析 

分 类 号：R969.3[医药卫生—药理学]