坦索罗辛、左氧氟沙星单用与联用治疗Ⅲ型前列腺炎的临床观察  

Clinical Observation of Tamsulosin and Levofloxacin Monotherapy and Their Combination in the Treatment of Ⅲ Prostatitis

作　　者：姚斌[1] 范晓萍[1] 邵四海[1] 

机构地区：[1]湖州师范学院附属第一医院,浙江湖州313000

出　　处：《中国药房》2015年第12期1624-1626,共3页China Pharmacy

摘　　要：目的:观察坦索罗辛、左氧氟沙星单用与联用治疗Ⅲ型前列腺炎的临床疗效和安全性。方法:将100例Ⅲ型前列腺炎患者随机分为坦索罗辛组(A组,40例)、左氧氟沙星组(B组,28例)和联合组(C组,32例)。A组患者口服盐酸坦索罗辛缓释胶囊0.2 mg,qd;B组患者口服左氧氟沙星片500 mg,qd;C组患者口服盐酸坦索罗辛缓释胶囊+左氧氟沙星片,用法用量同A、B组。各组疗程均为12周。比较各组患者治疗前、后的国立卫生研究院慢性前列腺炎症状指数(NIH-CPSI)和国际前列腺症状评分(IPSS)及不良反应发生情况。结果:治疗前,各组患者NIH-CPSI和IPSS总评分及各项评分比较,差异均无统计学意义(P>0.05);治疗后,各组患者NIH-CPSI和IPSS总评分及各项评分均较治疗前显著下降(P<0.05),且各组之间比较差异均无统计学意义(P>0.05)。各组患者治疗期间均未见明显不良反应发生。结论:坦索罗辛、左氧氟沙星单用与联用治疗Ⅲ型前列腺炎的疗效相似,安全性亦无明显差异。OBJECTIVE：To compare the clinical efficacy and safety of tamsulosin and levofloxacin monotherapy and their combination in the treatment of Ⅲ prostatitis. METHODS：100 patients with Ⅲ prostatitis were randomly divided into tamsulosin group（group A,n=40）,levofloxacin group（group B,n=28）and combination group（group C,n=32）. Patients in group A were orally given Tamsulosin release capsules 0.2 mg,qd;patients in group B were orally given Levofloxacin tablets 500 mg,qd;patients in group C were given Tamsulosin release capsules and Levofloxacin tablets with the same usage and dosage as group A and B. The course of 3 groups was 12 weeks. The clinic data was observed,including NIH-Chronic Prostatitis Symptom Index（NIH-CPSI）and International Prostate Symptom Score（IPSS）before and after treatment and the adverse reactions. RESULTS：Before treatment,there were no significant differences among the scores of NIH-CPSI,IPSS and others in 3 groups（P〉0.05）;after treatment,the scores of NIH-CPSI,IPSS and others in 3 groups were significantly decreased（P〈0.05）and there were no significant differences among 3 groups（P〉0.05）. There were no obvious adverse reactions during the treatment. CONCLUSIONS：The efficacy of tamsulosin and levofloxacin monotherapy is similar to the combination therapy in the treatment of Ⅲ prostatitis with similar safety.

关 键 词：坦索罗辛 左氧氟沙星 单用 联用 Ⅲ型前列腺炎 疗效 安全性 

分 类 号：R697.33[医药卫生—泌尿科学]