Prenylated indole alkaloids from the marine-derived fungus Paecilomyces variotii  

作　　者：Peng Zhang Xiao-Ming Li Jia-Ning Wang Xin Li Bin-Gui Wang 

机构地区：[1]Key Laboratory of Experimental Marine Biology,Institute of Oceanology,Chinese Academy of Sciences [2]University of Chinese Academy of Sciences

出　　处：《Chinese Chemical Letters》2015年第3期313-316,共4页中国化学快报（英文版）

基　　金：support from the Natural Science Foundation of China (No.31330009);the Ministry of Science and Technology of China (No.2010CB833802)

摘　　要：Two new prenylated indole alkaloids,namely,dihydrocarneamide A（1） and iso-notoamide B（2）,were isolated from the marine-derived endophytic fungus Paecilomyces variotii EN-291.The structures of these metabolites were determined based on comprehensive spectral analysis,together with chiral HPLC analysis of the acidic hydrolysates.Unlike other prenylated indole alkaloids such as asperparalines,notoamides,and versicolamides,compounds 1 and 2 are the rare examples of C-5 prenylation,forming the fused dimethyldihydropyran ring at C-5 and C-6 of the indole ring.The cytotoxic activity of the isolated compounds was evaluated.Two new prenylated indole alkaloids,namely,dihydrocarneamide A（1） and iso-notoamide B（2）,were isolated from the marine-derived endophytic fungus Paecilomyces variotii EN-291.The structures of these metabolites were determined based on comprehensive spectral analysis,together with chiral HPLC analysis of the acidic hydrolysates.Unlike other prenylated indole alkaloids such as asperparalines,notoamides,and versicolamides,compounds 1 and 2 are the rare examples of C-5 prenylation,forming the fused dimethyldihydropyran ring at C-5 and C-6 of the indole ring.The cytotoxic activity of the isolated compounds was evaluated.

关 键 词：Paecilomyces alkaloids indole endophytic fused fungus cytotoxic COSY Penicillium acidic 

分 类 号：O629.3[理学—有机化学]