Efficient synthesis of panaxadiol derivatives using continuous-flow microreactor and evaluation of anti-tumor activity  

作　　者：Yan Wu Wei-Qi Chen Yu-Qing Zhao Hu-Ri Piao 

机构地区：[1]Key Laboratory of Natural Resources and Functional Molecules of the Changbai Mountain,Affiliated Ministry of Education,Yanbian University College of Pharmacy [2]Department of Chemistry,Fudan University [3]School of Traditional Chinese Materia Medica,Shenyang Pharmaceutical University

出　　处：《Chinese Chemical Letters》2015年第3期334-338,共5页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China (Nos.81160381 and 81260468);the Natural Science Foundation of Jilin Province (No.201115235)

摘　　要：An efficient method has been developed for the synthesis of a series of（20R）-panaxadiol derivatives（4a–w） using a continuous-flow microreactor.The antitumor activities of the newly synthesized compounds were evaluated in vitro in two human prostate adenocarcinoma tumor cell lines（i.e.,PC-3and LNCa P cells）,and their cytotoxicities were evaluated using a standard MTT assay.Compounds 4c,4h,4p,4q and 4s exhibited higher antitumor activities toward PC-3 cell line than panaxadiol,which was used as a reference standard.An efficient method has been developed for the synthesis of a series of（20R）-panaxadiol derivatives（4a–w） using a continuous-flow microreactor.The antitumor activities of the newly synthesized compounds were evaluated in vitro in two human prostate adenocarcinoma tumor cell lines（i.e.,PC-3and LNCa P cells）,and their cytotoxicities were evaluated using a standard MTT assay.Compounds 4c,4h,4p,4q and 4s exhibited higher antitumor activities toward PC-3 cell line than panaxadiol,which was used as a reference standard.

关 键 词：antitumor adenocarcinoma toward silica batch shorter spectrometer incubated equiv acetate 

分 类 号：O623.4[理学—有机化学] TQ460.1[理学—化学]