Atrial fibrillation associated with tiotropium in patients with pre-existing arrhythmia: a case report  

心律失常患者使用噻托溴铵粉吸入剂引起房颤1例（英文）

作　　者：魏艳红[1,2] 杨莉萍[1] 张亚同[1] 邵宏[3] 

机构地区：[1]北京医院药学部,北京100730 [2]北京大学首钢医院药剂科,北京100144 [3]北京大学医学部 药学院 药事管理与临床药学系,北京100191

出　　处：《Journal of Chinese Pharmaceutical Sciences》2015年第3期192-194,共3页中国药学（英文版）

摘　　要：Inhaled anticholinergic agent tiotropium is widely used in the treatment of chronic obstructive pulmonary disease（COPD）. However, it has pro-arrhythmic and pro-ischaemic effects, which can potentially increase the risk of serious cardiovascular events, especially in patients with pre-existing arrhythmias. We presented a 79-year-old man with a medical history of arrhythmia, who developed atrial fibrillation after used tiotropium 18 μg daily for two weeks. We urge the caution of pro-arrhythmic effect of tiotropium. Healthcare professionals should be aware of the potential effect when prescribing tiotropium to patients with known cardiac rhythm disorders.吸入性抗胆碱能药物噻托溴铵广泛用于COPD的治疗。然而噻托溴铵有促心律失常促缺血作用,增加患者心血管事件的发生率。有心律失常疾病的患者,其发生率会更大。1例79岁男性患者,有心律失常病史,使用噻托溴铵粉吸入剂18μg,2次/天,2周后出现房颤,对症治疗后痊愈。噻托溴铵的促心律失常作用很容易被忽略,本文旨在提醒医务人员警惕噻托溴铵粉吸入剂在COPD患者中的促心律失常作用。

关 键 词：TIOTROPIUM Atrial fibrillation Adverse effects Patient education 

分 类 号：R541.75[医药卫生—心血管疾病]