二妙散加味联合西药治疗湿热下注型尖锐湿疣患者临床疗效及不良反应观察  

Clinical effect and adverse reactions of Ermiaosanjiawei combined with western medicine treatment on patients with Shirexiazhu type of genital warts

作　　者：舒国斌 王松挺 斯子翔 乔建军[2] 

机构地区：[1]宁波市北仑区人民医院皮肤科,浙江宁波315800 [2]浙江大学医学院第一附属医院皮肤科,杭州310003

出　　处：《中国性科学》2015年第3期47-50,共4页Chinese Journal of Human Sexuality

摘　　要：目的:探讨二妙散加味联合西药治疗湿热下注型尖锐湿疣患者临床疗效及不良反应观察,为临床诊断治疗提供参考。方法:将本组93例尖锐湿疣患者根据随机数字表法随机分为对照组(n=46)和观察组(n=47)。对照组给予疣必治局部用药治疗,观察组在对照组基础上结合二妙散加味治疗,两组疗程均为1个月。结果:观察组治疗后总有效率(95.74%)显著高于对照组(73.91%),且差异统计具有显著性意义(P<0.05);观察组治疗后伤口感染率(8.51%)和伤口愈合时间(6.17±2.34d)均明显低于对照组治疗后伤口感染率(54.35%)和伤口愈合时间(15.60±3.49d),且差异具有统计学意义(P<0.05);观察组随访3个月复发率(4.26%)显著低于对照组(26.09%),且差异具有统计学意义(P<0.05);两组患者均未发生明显的不良反应。结论:二妙散加味联合西药治疗湿热下注型尖锐湿疣患者临床疗效显著,且复发率低、未发生明显不良反应,临床上应用安全可靠,具有重要研究价值,值得进一步推广。Objectives： To investigate the clinical effect and adverse reactions of Ermiaosanjiawei combined with western medicine treatment on patients with Shirexiazhu type of genital warts,so as to provide reference for clinical diagnosis and treatment. Methods： 93 patients with genital warts were randomly divided into two groups according to the random number table,control group（ n = 46） and observation group（ n = 47）. The control group received topical treatment of Youbizhi. The observation group received Ermiaosanjiawei treatment on the basis of Youbizh for one month. Results： The total effective rate of observation group（ 95. 74%） was significantly higher（ 73. 91%） than the control group＇s after treatment and the difference was statistically significant（ P〈 0. 05）; the wound infection rate of observation group（ 8. 51%） and the mean wound healing time（ 6. 17 ± 2. 34d） were significantly lower than the wound infection rate（ 54. 35%） and the average healing time（ 15. 60 ± 3. 49d） of control group after treatment,with statistically significant difference（ P〈 0. 05）; relapse rate of observation group（ 4. 26%） was significantly lower than that of control group（ 26. 09%） after 3 month＇s treatment,with statistically significant difference（ P〈 0. 05）. There was no significant adverse reaction in the two groups. Conclusion： The effect and adverse reactions of Ermiaosanjiawei combined with western medicine treatment on patients with Shirexiazhu type of genital warts is significant,with low recurrence rate and fewer adverse reactions. The clinical application is safe and reliable,which is worthy of further promotion with important research value.

关 键 词：二妙散加味 西药 湿热下注型 尖锐湿疣 不良反应 

分 类 号：R752.53[医药卫生—皮肤病学与性病学]