氟康唑不同给药方案治疗复发性假丝酵母菌性阴道炎临床效果观察  

Clinical effect of different dosage regimen of fluconazole on the treatment of relapsed candida mycoderma bacteria

作　　者：陈文波[1] 葛芬芬[1] 

机构地区：[1]宁波市医疗中心李惠利医院妇科,浙江宁波315040

出　　处：《中国性科学》2015年第4期13-16,共4页Chinese Journal of Human Sexuality

摘　　要：目的:探讨氟康唑两种不同给药方案治疗复发性假丝酵母菌性阴道炎的临床效果,并为该类患者提供科学的用药指导。方法:选取我院妇科门诊于2010年6月至2011年5月治疗的42例复发性假丝酵母菌性阴道炎患者,设为对照组,指导患者首日单次服用氟康唑胶囊150mg,次日减少至100mg,1次/d,持续3周;选取我院妇科门诊于2011年6月至2012年5月收治的46例复发性假丝酵母菌性阴道炎患者,设为研究组,指导患者连续3d服用氟康唑胶囊150mg,1次/d,持续3周,次月月经后再次服用150mg。嘱患者于用药后1周及次月月经干净4周后进行妇科健康查体、真菌镜检等常规妇科检查,比较两组患者用药后临床总有效率及真菌清除率。结果:两组在用药1周后的临床疗效差异无统计学意义(P>0.05);下次月经干净后4周末,研究组痊愈31例,显效8例,有效5例,无效2例,有效率为84.8%,对照组痊愈25例,显效5例,有效6例,无效6例,有效率为71.4%,差异有统计学意义(P<0.05)。两组在用药后1周真菌清除率差异无统计学意义(P>0.05);下次月经干净后4周,研究组真菌清除率为91.3%,对照组为78.6%,差异有统计学意义(P<0.05)。结论:氟康唑巩固疗法和单次疗法均能有效治疗复发性假丝酵母菌性阴道炎,但巩固疗法的疗效更为突出,并能降低复发率,促使患者早日康复。Objectives： To investigate the clinical effect of different dosage regimen of fluconazole on the treatment of relapsed candida mycoderma bacteria and to provide scientific guidelines for the patients. Methods： 42 cases of relapsed candida mycoderma bacteria patients in our hospital from 2010 June to May 2011 were selected as control group,and the patients were given Fluconazole Capsules 150 mg once and 100 mg next day,once a day for three weeks; 46 cases of relapsed candida mycoderma bacteria patients in our hospital from June 2011 to May 2012 were selected as the study group,and the patients were given continuous administration of Fluconazole Capsules150 mg for 3 days,1 times / D,and was given 150 mg again the next monthly menstruation. After menstruation 1week and clean 4 weeks,gynecological health examination and microscopic fungi routine gynecological examination were done. Total clinical efficiency and fungal clearance rate of 2 groups were compared. Results： The clinical effect of the two groups after one week administration had no significant difference（ P〉 0. 05）; after the next menstrual clean 4W,the clinical effect of study group was higher than that of the control group（ P〈 0. 05）. The difference was statistically significant. The difference in 1W fungal clearance rates of the two groups was not statistically significant（ P〉 0. 05）; after the next menstrual clean 4W,fungal clearance rate of study group was higher than that of the control group,with statistically significant difference（ P〈 0. 05）. Conclusion： Fluconazole consolidation therapy and single therapy are both effective in the treatment of relapsed candida mycoderma bacteria,but the effect of consolidation therapy is more prominent,and can reduce the recurrence rate and promote early rehabilitation of patients.

关 键 词：复发性假丝酵母菌性阴道炎 治疗效果 总有效率 真菌清除率 

分 类 号：R711.31[医药卫生—妇产科学]