促卵泡生成激素受体多态性与多囊卵巢综合征易感性的Meta分析  

A Meta- analysis of FSHR Ser680Asn polymorphism and susceptibility of polycystic ovary syndrome

作　　者：王莹[1] 窦欣欣[2] 王若春 李磊[4] 

机构地区：[1]临朐县人民医院妇产科,山东潍坊262600 [2]潍坊市益都中心医院妇产科,山东潍坊262500 [3]青州市妇幼保健院妇产科,山东潍坊262500 [4]山东省立医院产科,济南250021

出　　处：《中国性科学》2015年第4期30-33,共4页Chinese Journal of Human Sexuality

摘　　要：目的:探讨促卵泡生成激素受体(FSHR)Ser680Asn位点多态性与多囊卵巢综合征(PCOS)的相关性。方法:通过Pubmed、Embase、Medline和国内数据库等,收集国内外已经发表的有关FSHR Ser680Asn位点多态性与多囊卵巢综合征易感性的文章,筛选出符合纳入和排除标准的文献,通过对各种模型比较,应用Stata12.0对各项研究进行异质性检验,计算合并OR值及其95%CI,并进行敏感性分析和发表偏移的评估。结果:9篇文献纳入本研究,共计PCOS病例1652例,对照4434例。Meta分析显示,总体人群Ser/Ser纯合子与PCOS有显著相关性(OR=0.20,95%CI=0.17-0.24,P=0.000),但在显性模型中未发现与PCOS有明显相关性(OR=1.1,95%CI=0.96-1.26,P=0.151),与之前报道结果不一致。结论:FSHR Ser/Ser纯合子与妇女PCOS的易感性相关。Objectives： To investigate the relation between polymorphism of FSHR Ser680 Asn and susceptibility of polycystic ovary syndrome（ PCOS）. Methods： The Pub Med,Embase,Medline database and Chinese databases were retrieved. The studies that met the inclusion criteria were collected. The software stata 12. 0 was used for statistical analysis. Sensitivity and publication bias were evaluated. Results： A total of 9 studies were collected which included 1652 ca-ses and 4434 controls cases. Meta- analysis showed that Ser / Ser homozygote and PCOS had significant correlation（ OR= 0. 20,95% CI = 0. 17- 0. 24,P = 0. 000）. But in dominant model,Ser / Ser homozygote and PCOS had no significant correlation（ OR = 1. 1,95% CI = 0. 96- 1. 26,P = 0. 151）,which was different from the former record. Conclusion：The results suggest that FSHR Ser / Ser homozygote have correlation with PCOS susceptibility.

关 键 词：促卵泡生成激素受体 基因多态性 多囊卵巢综合症 META分析 

分 类 号：R711.75[医药卫生—妇产科学]