Efficient Synthesis of a-Amino Acid Derivatives via Phase-transfer-catalyzed Directed Reductive Amination  

作　　者：ZHANG Xiaohua YE Wenjing WANG Kuanglei TIAN Yongshou XIAO Xiao 

机构地区：[1]School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, P. R. China

出　　处：《Chemical Research in Chinese Universities》2015年第2期203-207,共5页高等学校化学研究（英文版）

基　　金：Supported by the Natural Science Foundation of China（No.21402127）. Foundation of Liaoning Province Education Department（No.l,2013381）, PhD Research Startup Foundation of Liaoning Province（No.20131110）, and Career Dcvclopment Support Plan for Young and Middle-aged Teachers in Shenyang Pharmaceutical University.

摘　　要：An efficient phase-transfer-catalyzed directed reductive amination of α-keto esters was described using simple substituted benzyl amines as nitrogen source and K2CO3 as base at room temperature, giving a series of aliphatic a-amino acid derivatives in moderate to high yields（up to 99%）. Preliminary study on this asymmetric process showed that cinchona-derived phase transfer catalyst was elTective, aflbrding the corresponding product in 13% e.e. and 40% yield.An efficient phase-transfer-catalyzed directed reductive amination of α-keto esters was described using simple substituted benzyl amines as nitrogen source and K2CO3 as base at room temperature, giving a series of aliphatic a-amino acid derivatives in moderate to high yields（up to 99%）. Preliminary study on this asymmetric process showed that cinchona-derived phase transfer catalyst was elTective, aflbrding the corresponding product in 13% e.e. and 40% yield.

关 键 词：Direcled reductive amination： α-Amino acid： Phase transfer catalyst 

分 类 号：TQ463.4[化学工程—制药化工] O623.736[理学—有机化学]