艾滋病功能性治愈研究概况  

Reseasch review of functional cure for AIDS

作　　者：汪春付[1] 康文[1] 孙永涛[1] 

机构地区：[1]第四军医大学附属唐都医院传染科,西安710038

出　　处：《中国艾滋病性病》2015年第3期248-252,共5页Chinese Journal of Aids & STD

基　　金：国家"十二五"科技重大专项(2014ZX10001002)~~

摘　　要：高效抗反转录病毒治疗(HAART)能有效抑制艾滋病病毒(HIV)的复制,极大地降低了艾滋病的发病率和病死率,使艾滋病从一种致死性疾病转变为慢性病毒感染性疾病。然而,HAART无法彻底清除病毒,HIV可潜伏在病毒储存库中,根治艾滋病困难巨大。因此,能有效控制病毒复制并维持机体免疫功能,即功能性治愈,成为近期艾滋病治疗的目标。随着"柏林病人"和"密西西比婴儿"的报道,功能性治愈受到越来越多的关注。该文对艾滋病功能性治愈研究进行综述。In the era of highly active antiretroviral therapy（HAART）,viral replication can be effectively inhibited in HIV-infected patients.AIDS has been changed from a deadly infection into a chronic infectious disease with a great reduction of HIV-related morbidity and mortality.However,since the establishment of virus latent state in HIV reservoirs,eradication of HIV with antiretroviral reagents seems impossible.Therefore,to achieve a functional cure,which can effectively control viral replication and maintain immune function without any therapy,becomes the recent goal for the treatment of AIDS.With the ＂ Berlin patient＂ and ＂ Mississippi baby＂ being reported,functional cure attracts more and more attentions.In this review,recent studies for functional cure of AIDS are discussed.

关 键 词：艾滋病 功能性治愈 研究进展 

分 类 号：R512.91[医药卫生—内科学]