白头翁总皂苷-羟丙基-β-环糊精包合物微丸生物利用度研究  

Study on the Bioavailability of Pulsatilla Total Saponins-hydroxypropyl-β-cyclodextrin inclusion Clathrate Pellets

作　　者：管咏梅[1] 刘红宁[1] 杨明[1] 陈振华[1] 陈丽华[1] 张妮[1] 

机构地区：[1]江西中医药大学现代中药制剂教育部重点实验室,南昌330004

出　　处：《世界中医药》2015年第3期337-341,共5页World Chinese Medicine

基　　金：科技部十二五国家重大新药创制科技重大专项(编号:013ZX09103-002-001);江西省自然科学基金项目(编号:20122BAB215041);江西省教育厅科技落地计划项目(编号:赣财教[2011]243号)

摘　　要：目的:研究白头翁总皂苷-羟丙基-β-环糊精包合物微丸的生物利用度。方法:分别单剂量口服给药白头翁总皂苷和白头翁总皂苷-羟丙基-β-环糊精包合物微丸(200 mg/kg),采用LC-MS法测定大鼠血药浓度,根据大鼠体内血药浓度经时过程,计算相应的药代动力学参数。结果:白头翁总皂苷和白头翁总皂苷-羟丙基-β-环糊精包合物微丸AUC分别为574.82和1776.32μg/(L·h)。结论:白头翁总皂苷制成羟丙基-β-环糊精包合物微丸后生物利用度显著提高。Objective： To explore the bioavailability of Pulsatilla total saponins- hydroxypropyl-β- cyclodextrin clathrate pellets.Methods： The total Saponin of Pulsatilla Chinensis Regel and its OH-β-CD clathrate Pellets（ 200 mg / kg） were administered in rats respectively,the plasma levels were determined by LC-MS. Then the corresponding pharmacokinetic parameters based on the time process of blood drug concentration were calculated. Results： AUC of the Total Saponin of Pulsatilla Chinensis Regel and its OH-β-CD inclusion complex were 574. 82 and 1776. 32μg / L·h. Conclusion： The bioavailability of pulsatilla total saponins can be improved significantly by the technology of hydroxypropyl-β-cyclodextrin inclusion.

关 键 词：白头翁总皂苷 包合物 微丸 生物利用度 

分 类 号：R944[医药卫生—药剂学]