凝血因子与创伤止血  

Coagulation factor and traumatic hemostasis

作　　者：吕茂民[1] 王方[1] 赵雄[1] 章金刚[1] 

机构地区：[1]军事医学科学院野战输血研究所,北京100850

出　　处：《军事医学》2015年第3期211-215,共5页Military Medical Sciences

基　　金：国家863计划资助项目(2012AA021902)

摘　　要：凝血因子参与机体凝血过程的内、外源性途径,与机体抗凝系统相互协调,两者的动态平衡维持着体内血液正常的生理状态。该文从分子结构、理化特性、生理功能等方面对参与创伤止血相关的凝血因子进行了详述,同时,对其在创伤出血控制、凝血方面发挥的重要作用及相关凝血因子类制品的研究进展、使用现状进行了综述,以期为凝血因子类药物的研发及应用提供借鉴。Coagulation factors ,which are involved in the intrinsic and extrinsic coagulation process of organism ,perform mutual coordination with the anticoagulation system. The dynamic balance between them inorder to maintain the normal blood physiological state. The molecular structure, physicochemical properties, physiological function involved in the trau- matic bleeding hemostasis were detailed in this paper. Meanwhile, the importance of coagulation factors for trauma hemostasis and coagulation, the coagulation factor products, and their use were reviewed here to provide reference for the development of coagulation factors as drugs.

关 键 词：凝血因子 创伤 止血 

分 类 号：R641[医药卫生—外科学]