益气复脉注射液与参芍胶囊对冠心病心绞痛患者血管内皮细胞功能及血清髓过氧化物酶的影响  

Effects of Yiqi-Fumai injection and Shenshao capsule on vascular endothelial cell function in patients with angina pectoris of coronary heart disease and serum myeloperoxidase

作　　者：陶泽民 王东雁[2] 赵桂珍[2] 张国忠[2] 何凤玲[2] 陈鹏 周文江[2] 蔡瑞君[2] 

机构地区：[1]甘肃兰州市中医骨伤医院,730000 [2]甘肃酒泉市人民医院,735000 [3]甘肃省酒泉市第二人民医院,735000

出　　处：《国际中医中药杂志》2015年第4期319-323,共5页International Journal of Traditional Chinese Medicine

摘　　要：目的：探讨益气复脉注射液与参芍胶囊治疗冠心病心绞痛的疗效及对血管内皮细胞功能、血清髓过氧化物酶（myeloperoxidase, MPO）的影响。方法收集2013年1月－2014年1月甘肃省兰州市中医骨伤医院、酒泉市人民医院冠心病心绞痛患者90例，按随机数字表法分为治疗组50例、对照组40例，治疗组用益气复脉注射液联合参芍胶囊治疗；对照组采用氯吡格雷及美托洛尔等治疗。分别观察2组用药前后一氧化氮（NO）、6-酮-前列腺素Fla（6-keto-PGFLa）、内皮素（ET）、一氧化氮合酶（NOS）和 MPO、超氧化物歧化酶（SOD）、谷胱甘肽过氧化酶（GSH）的变化。结果治疗后，治疗组 NO、6-keto-PGFLa、NOS分别为（127.11±103.60）μmol/L、（50.03±60.87）pg/ml、（35.12±22.18）U/Ml，均较治疗前[（78.09±88.71）μmol/L、（32.04±25.82）pg/ml、（27.88±9.08）U/Ml]明显升高（P＜0.05）；对照组治疗后分别为[（95.62±6.31）μmol/L、（29.09±42.01）pg/ml、（30.11±7.51）U/Ml]，与治疗前[分别为（96.98±82.45）μmol/L、（40.31±51.92）pg/ml、（28.12±5.11）U/Ml]比较，6-keto-PGFLa 升高（P＜0.05）、NO、NOS变化不明显（P＞0.05）。治疗组ET[（42.47±40.5）pg/ml比（58.81±33.18）pg/ml]较治疗前降低（P＜0.05）；对照组ET[（60.67±12.81）pg/ml比（56.81±32.76）pg/ml]较治疗前降低（P＜0.05）。治疗组MPO、SOD、GSH分别为（17.11±3.60）mmol/L、（62.45±15.76）U/Ml、（35.98±28.19）g/L，均较治疗前（57.33±8.34）mmol/L、（48.36±17.38）U/Ml、26.68±19.93）g/L 改善；对照组治疗后分别为（48.62±6.31）mmol/L、（57.35±14.44）U/Ml、（28.56±24.06）g/L，治疗前分别为（56.98±8.45）mmol/L、（48.44±19.37）U/Ml、（29.44±21.66）g/L；2组治疗后比较，治疗组明显优于对照组（P＜0.05）。结论益气复脉注射液联合参芍胶囊治疗冠心病心绞痛疗效可靠。Objective To observe the therapeutic effect ofYiqi-Fumai injection andShenshao capsule in the treatment of angina pectoris and the influence on vascular endothelial cell function and serum MPO. Methods 90 cases of angina pectoris of coronary heart disease were randomly divided into a treatment group and a control group. 50 cases in the treatment group were treated withYiqi-Fumai injection and Shenshao capsule; 40 cases in the control group were treated with Plavix and metoprolol; clinical symptoms were observed before and after treatment, the indexes of endothelial cell function and electrocardiogram blood serum nitric oxide （NO）, endothelin （ET）, NOS and serum MPO, SOD, GSH changes were compared.Results The content of nitric oxide （NO）, 6-keto-PGFLa and NOS of the treatment group were increased than the control group, while ET was reduced. In the treatment group, NO was （78.09 ± 88.71）μmol/L 6-keto-PGFL was 32.04 ± 25.82 pg/ml and NOS was 27.88 ± 9.08 U/MI before the treatment,; after the treatment, the NO was 127.11 ± 103.60μmol/L, 6-keto-PGFLa was 50.03 ± 60.87 pg/ml and NOS was 35.12 ± 22.18 U/MI. In the control group, NO was 96.98 ± 82.45μmol/L, 6-keto-PGFLa was 40.31 ± 51.92 pg/ml and NOS was 28.12 ± 5.11 U/MI before the treatment; After the treatment, NO was 95.62 ± 6.31μmol/L, 6-keto-PGFLa was 29.09 ± 42.01 pg/ml and NOS was 30.11 ± 7.51 U/MI. In the treatment group, ET was 58.81 ± 33.18 pg/ml before the treatment and 42.47 ± 40.5 pg/ml. after the treatment. In the control group, ET was 56.81 ± 32.76 pg/ml before the treatment and 60.67 ± 12.81 pg/ml after the treatment. In terms of resistance to oxidative stress and MPO, the SOD ,GSH and MPO improvement rate of the treatment group was significantly better than the control group （P〈0.05）. In the treatment group, SOD was 48.36 ± 17.38 U/MI, GSH was 126.68 ± 19.93 g/L and MPO was 57.33 ± 8.34 mmol/L before the treatment, after the treatment, SOD was 62.45 ± 15.76 U/MI, GSH was 135.98 ± 28.99 g/L and MPO was 17.

关 键 词：益气复脉 参芍胶囊 冠心病心绞痛 血管内皮细胞 血清髓过氧化物酶 

分 类 号：R259[医药卫生—中西医结合]