组蛋白去乙酰化酶在支气管哮喘致病过程中的作用  

The role of histone deacetylase enzymes in the pathogenesis of bronchial asthma

作　　者：任媛[1] 苏新明[1] 康健[1] 

机构地区：[1]中国医科大学附属第一医院呼吸内科,沈阳110001

出　　处：《国际呼吸杂志》2015年第7期524-527,共4页International Journal of Respiration

摘　　要：支气管哮喘（简称哮喘）是一种以气道炎症、气道重塑和气道高反应为主要病理变化的过敏性气道疾病,而染色质修饰在这一过程中发挥着重要作用.其中组蛋白的乙酰化和去乙酰化修饰占有重要地位,在基因转录活跃区,核心组蛋白的乙酰化活性高;在非活跃区,核心组蛋白的乙酰化程度低[1].在体内组蛋白的乙酰化和去乙酰化是动态可逆的,如果该平衡在特定的条件下被破坏,就会导致基因转录失调,从而引起基因表达的异常.在哮喘的致病过程中,组蛋白的乙酰化与去乙酰化修饰均发生了不同程度的改变,参与了哮喘气道炎症、气道重塑和气道高反应的形成.近年来大量实验已经证实了组蛋白去乙酰化酶抑制剂具有抗炎抗氧化和抗细胞增生等一系列的作用,根据组蛋白去乙酰化酶在正常和病变的气道和肺组织中表达差异的研究,以及组蛋白去乙酰化酶抑制剂对肺结构细胞和炎症细胞的影响,推测应用组蛋白去乙酰化酶抑制剂治疗哮喘可能缓解气道炎症、气道重塑和气道高反应[2].Airway inflammation,airway remodeling and airway hyperresponsiveness are major aspects of bronchial asthma （asthma） pathology.Gene modification such as acetylation plays an important role in the progress.The core histone acetylation activity is high in the active region of gene transcription,while at the non-active region,a low degree of acetylation[1].As a dynamic reversible progress,if the balance is destroyed,it will lead to the gene transcription disorders,causing the abnormal gene expression.In the pathogenesis of asthma,histone acetylation and deacetylation modification changed differently,which participated in the formation of airway inflammation,airway remodeling and hyperresponsiveness.In recent years,a large number of experiments have confirmed that histone deacetylase inhibitors have anti-inflammatory,antioxidant and anti-proliferative effects.According to study the differences of histone deacetylation in normal and abnormal lung tissue and the effects of histone deacetylase inhibitors to the lung structure cells and inflammatory cells,we speculated that histone deacetylase inhibitors may alleviate asthma airway inflammation,airway remodeling and airway hyperresponsiveness[2].

关 键 词：组蛋白乙酰基转移酶 组蛋白去乙酰化酶 组蛋白去乙酰化酶抑制剂 哮喘 气道炎症 气道重塑 气道高反应 

分 类 号：R562.25[医药卫生—呼吸系统]